Brabender, described by pitcher Steve Barber as "a hard-throwing right-handed country boy,"[2] made his Major League debut in relief on May 11, 1966. He entered a tie game against the Chicago White Sox in the top of the 10th inning at Memorial Stadium and gave up a run in the 11th, resulting in a 3–2 Orioles loss.[3] He was part of the Orioles' 1966 World Series champion team, but did not appear in a World Series game. Brabender was 16–14 with a 3.39 ERA in 82 games (30 starts) during his time in Baltimore.[4] He pitched the best game of his career on August 7, 1967, against the Cleveland Indians, tossing a four-hit shutout while striking out 12 batters.[5]
He along with Gordon Lund was traded from the Orioles to the Seattle Pilots for Chico Salmon on March 31, 1969.[6] Brabender led Seattle with 13 wins in their only season in the Pacific Northwest.[4] The Pilots moved to Milwaukee during 1970 spring training and became the Brewers, and in what would be his final season, Brabender compiled a 6–15 record with one save and a 6.02 ERA in 29 games (21 starts).[4]
Brabender died of a brain aneurysm at age 55 on December 27, 1996.[1]