He then spent the entire 1960 season on the San Francisco roster, working in 17 games, with four starts. On August 21, he earned his first MLB win when he went seven innings in a start at Wrigley Field against the Chicago Cubs, and held the home team to seven hits and three earned runs. The Giants won the game, 5–3.[3] However, this became Maranda's only victory (against four losses) in that 1960 campaign. He was assigned to Triple-A Tacoma at the close of the year and spent all of 1961 in the Pacific Coast League, posting a 10–4 win–loss record through 32 games.
The Twins then selected Maranda in the 1961 Rule 5 draft and kept him on their roster for the 1962 campaign.
On June 22, he made a spot start (just his second of the season) against the Los Angeles Angels at Metropolitan Stadium, leaving the game for a pinch hitter in the fifth inning, trailing 2–0. Minnesota then rallied in that inning to take a 3–2 lead, which they held for the rest of the game.[4] It was Maranda's only triumph as a member of the Twins and his second and last MLB victory. A week after the season ended, Maranda was traded to the Cleveland Indians, after which he never again pitched in the big leagues, retiring after spending the 1963 season with the Triple-A Jacksonville.
In 1973–1974, he coached the Québec Carnavals in the Eastern League. Also in 1973, his hometown of Lévis, Québec, honoured him by naming its baseball park the George Maranda Stadium. In June, 2000, he was elected to the Québec Baseball Hall of Fame.
Georges Maranda is interred in the Mont-Marie Cemetery, Lévis, Chaudiere-Appalaches Region, Quebec, Canada.