The Gros-de-Vaud lies between the cities of Lausanne and Yverdon on the North-South direction, and between Moudon and Orbe in the East-West axle. The community of Echallens is its centre and the head of the Gros-de-Vaud district that was created on January 1, 2008.
Close to the Lausanne agglomeration (capital of the canton of Vaud), the Gros-de-Vaud is connected to it by the Lausanne-Echallens-Bercher (LEB) railroad.