HIC1

HIC1
Identifiers
Aliases	HIC1, ZBTB29, ZNF901, hic-1, hypermethylated in cancer 1, HIC ZBTB transcriptional repressor 1
External IDs	OMIM: 603825; MGI: 1338010; HomoloGene: 4740; GeneCards: HIC1; OMA:HIC1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	2,063,241 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,060,345 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; stromal cell of endometrium; ; apex of heart; ; sural nerve; ; vena cava; ; right ovary; ; left ovary; ; left uterine tube; ; body of uterus; ; pericardium;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; vas deferens; ; efferent ductule; ; Gonadal ridge; ; female urethra; ; dermis; ; placenta; ; gastrula; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; histone deacetylase binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	chromatin; nucleus; cytosol; nucleoplasm;
Biological process	multicellular organism development; negative regulation of Wnt signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; intrinsic apoptotic signaling pathway in response to DNA damage; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	3090
	15248
	ENSG00000177374
	ENSMUSG00000043099
	Q14526
	Q9R1Y5
	NM_006497; NM_001098202
	NM_001098203; NM_010430
	NP_001091672; NP_006488
	NP_001091673; NP_034560
	Wikidata
View/Edit Human	View/Edit Mouse

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177374 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043099 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HIC1 hypermethylated in cancer 1".

Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]". Med Sci (Paris). 22 (1): 54–61. doi:10.1051/medsci/200622154. PMID 16386221.
Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3". Nat. Med. 1 (6): 570–7. doi:10.1038/nm0695-570. PMID 7585125. S2CID 21993943.
Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer". Oncogene. 16 (16): 2159–64. doi:10.1038/sj.onc.1201976. PMID 9572497.
Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved". Biochim. Biophys. Acta. 1443 (1–2): 230–2. doi:10.1016/s0167-4781(98)00219-x. PMID 9838134.
Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831–6. Bibcode:1999PNAS...9614831D. doi:10.1073/pnas.96.26.14831. PMC 24733. PMID 10611298.
Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53". J. Biol. Chem. 276 (5): 3078–89. doi:10.1074/jbc.M008690200. PMID 11073960.
Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem. Biophys. Res. Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif". Mol. Cell. Biol. 22 (13): 4890–901. doi:10.1128/MCB.22.13.4890-4901.2002. PMC 133903. PMID 12052894.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms". Clin. Cancer Res. 9 (10 Pt 1): 3674–8. PMID 14506157.
Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas". J. Neuropathol. Exp. Neurol. 62 (11): 1192–201. doi:10.1093/jnen/62.11.1192. PMID 14656076.
Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling". Carcinogenesis. 25 (5): 661–8. doi:10.1093/carcin/bgh055. PMID 14688019.
Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1". Oncogene. 23 (22): 4023–31. doi:10.1038/sj.onc.1207504. PMID 15007385.
Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties". J. Biol. Chem. 279 (37): 38313–24. doi:10.1074/jbc.M401610200. PMID 15231840.
Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis". Cancer Cell. 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761.
Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1". Oncogene. 25 (14): 2030–9. doi:10.1038/sj.onc.1209240. PMID 16301995. S2CID 27624320.
Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies". EMBO J. 25 (11): 2326–37. doi:10.1038/sj.emboj.7601147. PMC 1478201. PMID 16724116.
Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP". FEBS J. 273 (13): 2879–90. doi:10.1111/j.1742-4658.2006.05301.x. PMID 16762039. S2CID 34249691.

External links

HIC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177374 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043099 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HIC1 hypermethylated in cancer 1".

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HIC1

References

Further reading

External links