After completing his education in Zwickau 1961, he became a soldier in the Nationale Volksarmee of the GDR. He studied Physics in Leipzig from 1963 to 1968, where he completed his Diplom under Hans-Juergen Treder.[2] After fleeing to West Germany, Fritzsch continued his studies in Munich where he finished his Ph.D. under the supervision of Heinrich Mitter.
In 1970 Fritzsch visited the Aspen Center for Physics, where he met Murray Gell-Mann. They started a collaboration, first in Aspen, later at the California Institute of Technology. In 1971 they introduced the concept of the colour charge quantum number which allowed them in collaboration with William A. Bardeen to explain the decay rate of pions. In the fall of 1971 Fritzsch and Gell-Mann moved to Geneva in Switzerland, where they worked together at CERN. They proposed a gauge theory for the strong interaction, which now is called Quantum Chromodynamics. In September 1972 they moved back to Caltech. In 1975 Fritzsch published a paper together with Peter Minkowski[3] in which they proposed the symmetry group SO(10) as the symmetry of the grand unified theory which has become a standard theory. In 1976 Fritzsch moved to CERN. After working for one year at the University of Wuppertal and the University of Bern, Fritzsch was appointed Professor at the Ludwig Maximilian University of Munich in 1980.
Fritzsch worked also on "composite models" of leptons and quarks, mass matrices of quarks and leptons, weak decays of heavy quarks, cosmology and the fundamental constants of physics. He retired in 2008 and died 16 August 2022 in München.[4]
In 1971 Fritzsch married Brigitte Goralski. They had two children.