IL1RAP

IL1RAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O4O, 4DEP
Identifiers
Aliases	IL1RAP, C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDs	OMIM: 602626; MGI: 104975; HomoloGene: 1643; GeneCards: IL1RAP; OMA:IL1RAP - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	190,659,750 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	26,548,867 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; placenta; ; blood; ; Achilles tendon; ; hair follicle; ; gingival epithelium; ; olfactory zone of nasal mucosa; ; gallbladder; ; germinal epithelium; ; monocyte;
	Top expressed in
	left lobe of liver; ; lumbar subsegment of spinal cord; ; medial geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; medial dorsal nucleus; ; primary oocyte; ; habenula; ; lateral geniculate nucleus; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1 receptor activity; protein tyrosine kinase binding; interleukin-33 receptor activity; signal transducer activity; interleukin-1 receptor binding;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane; extracellular space; glutamatergic synapse;
Biological process	innate immune response; inflammatory response; immune response; signal transduction; cytokine-mediated signaling pathway; immune system process; positive regulation of NF-kappaB transcription factor activity; positive regulation of dendrite development; interleukin-33-mediated signaling pathway; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of synapse assembly; protein-containing complex assembly; interleukin-1-mediated signaling pathway; regulation of postsynaptic density assembly; trans-synaptic signaling by trans-synaptic complex; synaptic membrane adhesion; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	3556
	16180
	ENSG00000196083
	ENSMUSG00000022514
	Q9NPH3
	Q61730
NM_001167928; NM_001167929; NM_001167930; NM_001167931; NM_002182;
	NM_134470; NM_001364879; NM_001364880; NM_001364881
	NM_001159317; NM_001159318; NM_008364; NM_134103
NP_001161400; NP_001161401; NP_001161402; NP_001161403; NP_002173;
	NP_608273; NP_001351808; NP_001351809; NP_001351810
	NP_001152789; NP_001152790; NP_032390; NP_598864
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.^[5]^[6]^[7]

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.^[7]

Interactions

IL1RAP has been shown to interact with TOLLIP^[8] and Interleukin 1 receptor, type I.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196083 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022514 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
^ ^a ^b "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
^ Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
^ Huang J, Gao X, Li S, Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

External links

Overview of all the structural information available in the PDB for UniProt: Q9NPH3 (Human Interleukin-1 receptor accessory protein) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q61730 (Mouse Interleukin-1 receptor accessory protein) at the PDBe-KB.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196083 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022514 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479509-5] Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.

[pmid9065432-6] Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.

[entrez-7] "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".

[pmid10854325-8] Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.

[pmid9371760-9] Huang J, Gao X, Li S, Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

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IL1RAP

Interactions

References

Further reading

External links