Ibuproxam

Ibuproxam
Clinical data
ATC code	M01AE13 (WHO) ;
Identifiers
	IUPAC name N-Hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide;
CAS Number	53648-05-8 ;
PubChem CID	68704;
DrugBank	DB08955 ;
ChemSpider	61955 ;
UNII	O3LD16O96Z;
KEGG	D07268 ;
ChEBI	CHEBI:76160 ;
ChEMBL	ChEMBL292707 ;
CompTox Dashboard (EPA)	DTXSID30866353 ;
ECHA InfoCard	100.053.331
Chemical and physical data
Formula	C13H19NO2
Molar mass	221.300 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	119–121 °C (246–250 °F)
	SMILES O=C(NO)C(c1ccc(cc1)CC(C)C)C;
	InChI InChI=1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15) ; Key:BYPIURIATSUHDW-UHFFFAOYSA-N ;
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Ibuproxam is a nonsteroidal anti-inflammatory drug (NSAID).It is the hydroxamic acid of ibuprofen to which it is hydrolyzed in the blood. It was found, that ibuproxam is considerably less damaging to the gastrointestinal tract than is ibuprofen. The analgesic and the antipyretic activities are consistent.^[1]

References

^ Orzalesi G, Selleri R, Caldini O, Volpato I, Innocenti F, Colome J, Sacristan A, Varez G (1977). "Ibuproxam and ibuprofen. A pharmacological comparison". Arzneimittel-Forschung. 27 (5): 1006–12. PMID 577862.

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