Since receiving his PhD in chemical physics at the University of Chicago in 1973, John Tyson has been studying temporal and spatial organization in chemical, biochemical and biological systems. Recently he has focused on the macro-molecular reaction networks that process information in living cells and initiate appropriate responses in terms of cell growth, division and death. He represents the dynamics of these reaction networks in terms of mathematical equations, using computer simulations to work out the precise behavior to be expected of the network. By comparing simulations with experimental data, the computer models can be tested, refined and developed, eventually, into tools for accurate predictions of the physiological responses of healthy and diseased cells.[2]
In John J. Tyson's laboratory they study biological systems from a rigorous mathematical perspective, and build realistic models that help gain a deeper understanding of the physiology. Most of their work is on the mechanism of cell cycle control as seen in budding yeast, fission yeast, Xenopus embryos and egg extracts, Drosophila embryos and mammalian cells.
Tyson also worked in chemical kinetics studying oscillations, bistability, traveling' waves, and chaotic behavior in chemical reaction systems.
The unifying theme of the research is the problem of spatial and temporal organization in chemical, biochemical and biological systems. What mechanisms keep time in these various domains? How is spatial information communicated and utilized? How do the molecular regulatory mechanisms of living cells process information and initiate appropriate responses in terms of cell growth, division and death?[3]
John has worked closely with high-profile individuals within the field of cell biology. Cell Cycle Control by a Minimal Cdk Network was written by John in tandem with Claude Gerard, Damien Coudreuse, and Béla Novák. The paper has been highly cited and takes a critical look at the possible origin of the eukaryotic cell and how the minimal cdk network can apply to larger complex cells like those found in humans. John has been featured on television for the annual meeting of the society of cell biology in 2013, as well as being featured on the National Institute of General Medical Sciences website.
Awards
1989-The Bellman Prize, Mathematical Biosciences
1992-Alumni Award for Research Excellence, VPI&SU
2000-Doctor honoris causa, Technical University of Budapest
2004-Virginia Outstanding Scientist of 2004
2007-Aisenstadt Chair, Centre de Recherches Mathematiques, U. Montreal
2009-Ziwet Lecturer, Department of Mathematics, University of Michigan
2009-Associate Member, Royal Academy of Sciences, Belgium
2011-Arthur T. Winfree Prize, Society for Mathematical Biology[7]
Membership and Offices in Professional Organizations
Member: American Association for the Advancement of Science, Society for Mathematical Biology, Society for Industrial and Applied Mathematics.
President, Society for Mathematical Biology (1993–95)
Editorial Board, Journal of Theoretical Biology (1989–present).
Co-Chief Editor, Journal of Theoretical Biology (1995-2004).
Co-Chair, Gordon Research Conference on Theoretical Biology and Biomathematics (1982).
Chair, Gordon Research Conference on Oscillations and Dynamic Instabilities in Chemical Systems (1997).
Chair, Cold Spring Harbor Symposium on Computational Cell Biology (2007, 2009)
Director, Biological Switches and Clocks, Kavli Institute of Theoretical Physics, Santa Barabara CA (2007).
Instructor, Cold Spring Harbor Course on Computational Cell Biology (2008, 2009).
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