Almira Woodruff (died 1844) Olive Thompson (m. 1848; died 1900)
Children
2 with Almira Woodruff Lawrence J. Elizabeth 5 with Olive Thompson Thomas J. Millard F. Lucy (b. 1853; died 1853) Bertha (b. 1856; died 1868) George Clifford (b. 1858)
Prentice represented Dodge County in the Wisconsin State Senate for two years. In 1852, as the senator from the 10th District, and in 1853, after redistricting, as the senator from the 22nd District. Additionally, he was an alderman of Watertown, Wisconsin, Surveyor of Dodge County, and a justice of the peace. He was a member of the Whig Party.