Keller began her career as a journalist as an intern for columnist Jack Anderson.[5] She went on to work for over 25 years as a reporter for many major newspapers, including The Columbus Dispatch, The Daily Independent, and the Chicago Tribune.[4][5] She joined the staff of the Chicago Tribune in late 1998.[5] She was formerly employed as a cultural critic for the Chicago Tribune, but left her job in 2012 to write full-time.[2][6]
Keller won the annual Pulitzer Prize for Feature Writing for her three-part narrative account of the deadly Utica, Illinois tornado outbreak, published by the Chicago Tribune in April 2004. The jury called it a "gripping, meticulously reconstructed account of a deadly 10-second tornado".[1] The Tribune has won many Pulitzers but Keller's prize was its first win for feature writing.
In 2008, Keller wrote a nonfiction book that detailed the cultural impact of the Gatling gun. In 2012, she started publishing a series of mysteries, The Bell Elkins Mysteries, that details a woman's return to Appalachia and the mysteries that abound in her home town.[2] The first book in the series. starred reviews from Publishers Weekly, Library Journal, Kirkus, and Booklist. It was also a winner of the Barry Award for Best First Mystery.