Ismael was selected by the Washington Football Team in the fifth round (156th overall) of the 2020 NFL Draft, in which they took Ismael with one of the two picks they acquired in a trade that sent Trent Williams to the San Francisco 49ers.[6] He signed his four-year rookie contract on July 22, 2020.[7] Ismael was released on August 31, 2021,[8] and re-signed to the practice squad the following day.[9] He was promoted to the active roster on November 4.[10] In the Week 12 win against the Seattle Seahawks, Ismael took over at center after starter Wes Schweitzer left the game after suffering an ankle injury.[11] The following week, Ismael made his first career start against the Las Vegas Raiders which made him the fourth starting center for the team in the 2021 season.[12]
On March 16, 2022, the team placed an exclusive-rights free agent tender on Ismael,[13] which he signed on April 20.[14] He was placed on injured reserve as part of finalizing the 53-man roster, but released with an injury settlement on September 5, 2022.[15][16]
San Francisco 49ers
On September 13, 2022, Ismael signed with the practice squad of the San Francisco 49ers.[17] He signed a reserve/future contract on January 31, 2023.[18]
On August 29, 2023, Ismael was waived by the 49ers.[19]