Atrophoderma vermiculatum is characterized by the formation of keratotic, inflammatory papules on the face that atrophicate, leave behind pitted scars that resemble honeycombs or reticula.[3]
The aberrant keratinization of the follicular infundibulum causes keratosis pilaris atrophicans, which is characterized by irritation and blockage of the growing hair shaft. Alopecia, fibrosis, atrophy, and shrinking of the hair bulb are caused by persistent inflammation. The possibility that the genes controlling follicular keratinization are located on chromosome 18p is suggested by the association with a number of congenital disorders caused by partial monosomy or deletion in chromosomal arm 18p.[5]
It has been demonstrated that a mutation in the desmoglein 4 gene causes autosomal recessive keratosis pilaris atrophicans.[6]
Diagnosis
Keratosis pilaris atrophicans can be diagnosed clinically. Usually, a skin biopsy is not required to make the diagnosis. When carried out, it exhibits general characteristics such as modest perifollicular inflammatory infiltration and keratotic plugs in the pilosebaceous units.[5]
Treatment
For keratosis pilaris atrophicans, there are no proven treatment options. With age, the condition frequently becomes better. It is advised to use ultraviolet (UV) protection because the condition is frequently made worse by light.[5]
^Lee, Young Chae; Son, Sook-Ja; Han, Tae Young; Lee, June Hyunkyung (2018). "A Case of Atrophoderma Vermiculatum Showing a Good Response to Topical Tretinoin". Annals of Dermatology. 30 (1). Korean Dermatological Association and The Korean Society for Investigative Dermatology: 116. doi:10.5021/ad.2018.30.1.116. ISSN1013-9087.
