On the outbreak of the Revolt in the Vendée against the Republic, he was arrested and imprisoned with all his family, as one of the promoters of the rising. He was set free by the Royalists and became one of their leaders.[1] Lescure fought at Thouars in May 1793.[1] At the Battle of Fontenay-le-Comte, he was the first to enter the city and free the Royalist prisoners inside. He was wounded at the Battle of Saumur in June. After an unsuccessful attack on Nantes, he joined forces with La Rochejaquelein and tried in vain to rally the troops of the dispersed Catholic and Royal Army.
Their peasant troops, opposed to the French Revolutionary Army General François Joseph Westermann, sustained multiple defeats, but finally gained a victory between Tiffauges and Cholet on 19 September 1793. He was seriously wounded by a bullet to the head at Tiffauges. The struggle was then concentrated around Châtillon, which was time after time taken and lost by the Republicans. Lescure was killed near the château of La Tremblaye at the Battle of La Tremblaye, between Ernée and Fougères.[1]