Luciano made his Série A debut on 13 October 2012, coming from the bench and scoring the last in a 3–1 home win against Internacional.[3] He contributed with five league appearances during the campaign, suffering team relegation.
In 2013 Luciano moved to Avaí in the Série B. He again made his debut with a goal, netting his team's only in a 3–1 loss at Chapecoense.
On 13 February 2014, Luciano signed a three-year contract with Corinthians in the top level.[4] He made his debut for the club nine days later, replacing Romarinho in a 3–2 Campeonato Paulista home win against Rio Claro.
Luciano subsequently scored two braces for Timão, in a 3–0 home win against Comercial and in a 4–0 away routing of Linense. On 22 August 2014 he scored a hat-trick in a 5–2 home success over Goiás.
On 19 August 2015, in a match against Santos for the national cup, Luciano suffered a serious knee injury.[5] He was sidelined for seven months, returning to action in February of the following year.[6]
On 24 August 2016, Luciano was loaned to La Liga side CD Leganés for one year, with a buyout clause.[7]
Panathinaikos, Fluminense and Grêmio
On 17 July 2017, Luciano joined Greek Superleague club Panathinaikos on loan until the end of the year.[8] On 20 September 2017, Luciano suffered a serious cruciate rupture injury during Greek Cup's clash against AEL in Leoforos. He was expected to return to action in March 2018.
In the end of 2018 he went to Fluminense.
In 2019, he moved to Grêmio.
São Paulo
On 18 August 2020, Luciano signed until December 2022 with São Paulo FC. He came to Tricolor after Éverton signed with Grêmio, and going to Luciano's opposite side.[9]
International career
Luciano was called for the Brazil U23 team representing the country at the 2015 Pan American Games in Toronto, Ontario, Canada.[10] He was the tournament's top goalscorer with five goals in only four matches, and won a Bronze medal.[11]