In Nashville, Price worked several jobs, including waiting tables, installing and removing residential siding, and teaching children to dance at a YMCA.[14] Price and her husband, guitarist Jeremy Ivey, were part of Secret Handshake, a band that only played political songs before she and Ivey started Buffalo Clover and later formed Margo and the Pricetags, which she says was "supposed to be a supergroup."[12] recording artist Sturgill Simpson and Kenny Vaughan, longtime guitarist in Marty Stuart's band, have both been in the lineup at various times.[12]
Rolling Stone Country described Price as "a fixture of the East Nashville music community,"[8] and appeared on that publication's list of Country Artists You Need to Know in 2014.[15] Fellow Nashville musician Aaron Lee Tasjan calls her "a singular and vital part of this scene, as a thing unto herself."[14]
Price has proven to be popular in the UK, with her album reaching number 1 on the UK Country Albums Chart, embarking on UK tours in 2016 and 2017, performing on Later... with Jools Holland and at the Glastonbury Festival[19] as well as garnering three nominations from the UK Americana Awards.[20] She performed as part of the C2C: Country to Country festival in 2018.
In her concerts, Price plays acoustic guitar and electric guitar and sings. In addition there is a second drum kit on stage, and as part of a coda for one or another of her songs, she plays those drums for a several-minute jam with the rest of the band.[21] On July 27, 2017, Price released a four-track EP titled Weakness,[22] followed on October 20, 2017, by her second album, All American Made. On July 10, 2020, she released her third album, That's How Rumors Get Started.[6]
On April 8, 2021, it was announced that Price had joined the board of directors for Farm Aid, along with Willie Nelson's wife Annie.[23] On October 4, 2022, Margo released her first memoir, Maybe We’ll Make It: A Memoir, published by University of Texas Press.[24] Her fourth album, Strays, was issued in January 2023.[25]
In 2024, Price collaborated with Mike Campbell (formerly of Tom Petty and the Heartbreakers) to cover Petty's song "Ways to be Wicked" for the Petty Country Tribute Album. Campbell and Price have previously collaborated on the Dirty Knobs song, "State of Mind", and her own song "Light Me Up". She also worked with Orville Peck on the track "You're an Asshole, I Can't Stand You (And I Want a Divorce)" for his duets album Stampede, released in August 2024.[26]
Price is married to Jeremy Ivey, who plays guitar in her band. In 2010, Price gave birth to twin boys, one of whom died shortly after birth. On June 4, 2019, Price had their third child, a girl.[28]