Guaipe was signed by the Seattle Mariners as an undrafted free agent in 2006. The Mariners added Guaipe to their 40-man roster on November 20, 2014, in order to protect him from the Rule 5 draft.[1] He made his major league debut against the New York Yankees in relief of Félix Hernández at Safeco Field on June 1, 2015, retiring all seven batters he faced and recording two strikeouts.[2] Guaipe would be optioned back down to the Tacoma Rainiers on June 2.
The Mariners released Guaipe on August 4, 2016. He re–signed with the organization on a minor league contract two days later. In 12 games for the Triple–A Tacoma Rainiers, Guaipe compiled a 3.14 ERA with 13 strikeouts and 4 saves across 14+1⁄3 innings pitched. He elected free agency following the season on November 7.[3]
Chicago White Sox
On January 27, 2017, the Chicago White Sox signed Guaipe as a free agent. He was released on March 26, 2017.