After completing his undergraduate studies, Knight broke into the fashion industry in Atlanta, Georgia by working as an intern at Wilbourn Exclusives in 2001[4] and then by becoming a fashion stylist in the music industry in 2002.[5]
In 2005, Knight auditioned for the second season of the Bravo network reality television series, Project Runway, but he was not accepted as a season two contestant.[4] In 2006, Knight reauditioned for Project Runway, and this time he was accepted as a contestant for season three. Knight went on to win season three's Fan Favorite award and to place fourth in the overall competition.[6]
In 2007, Knight introduced his label, Mychael Knight, on BET's Rip the Runway[7] and he designed a line of custom tees for the Starbucks Corporation.[8]
In 2008, Knight launched Kitty & Dick, his female and male lingerie label,[9] and his unisex fragrance, MajK.
Knight died on October 17, 2017, at the age of 39.[13] His cause of death remains a mystery. He had been open about his battle with irritable bowel syndrome and extreme weight loss in recent months, leaving many to wonder if the disease may have played a role in his death. Doctors believe that unlikely, however.[14]