Nicotinate dehydrogenase

In enzymology, a nicotinate dehydrogenase (EC 1.17.1.5) is an enzyme that catalyzes the chemical reaction

nicotinate + H₂O + NADP⁺ ${\displaystyle \rightleftharpoons }$ 6-hydroxynicotinate + NADPH + H⁺

The 3 substrates of this enzyme are nicotinate, H₂O, and NADP⁺, whereas its 3 products are 6-hydroxynicotinate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with NAD⁺ or NADP⁺ as acceptor.

The systematic name of this enzyme class is nicotinate:NADP⁺ 6-oxidoreductase (hydroxylating). Other names in common use include nicotinic acid hydroxylase, and nicotinate hydroxylase.

This enzyme participates in nicotinate and nicotinamide metabolism. It has 2 cofactors: FAD, and Iron.

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