At the age of 18, Zehetner started an acting career, something she had been interested in since she was 8, and moved to Los Angeles. She appeared in Tart (2001), American Pie 2 (2001), R.S.V.P. (2002), May (2002), and The Song of Rose (2003), as well as in other films and several TV series and commercials. Zehetner portrayed Laynie Hart on the WB's show Everwood.
In 2007, Zehetner appeared with Marisa Berenson in the short movie Jalouse: Elegante, famous, beautiful, jolie which was produced by the French fashion magazine Jalouse to celebrate their 10th anniversary.[3]
Zehetner portrayed the recurring role of Dr. Reed Adamson for 10 episodes during the sixth season (2009–2010) of the television series Grey's Anatomy.
Zehetner portrayed Jen, Marc Maron's girlfriend on the TV series Maron.[4]
In 2018, Zehetner was cast in the recurring role of Valeria Poriskova on the second season of the ABC political drama Designated Survivor.[5]