The site of Nyssa has been identified as near the modern town of Harmandalı, Ortaköy district, Aksaray province, in south-central Turkey.[3] The archaeological site consists of two tells, named Büyükkale (Great Castle) and Küçükkale (Little Castle), located 1 and 2 km to the north of Harmandalı with the town located 1 km north[1]
Another proposed location associates it with the modern city of Nevşehir, but modern scholarship has cast serious doubt on this.[1][4]
William Smith's Dictionary of Greek and Roman Geography placed the town at a village, not otherwise mentioned, called Nirse or Nissa and said that it was anciently in a district called Muriane, not far from the river Halys.[5]
The Eastern Orthodox Church has continued to appoint titular bishops of Nyssa even after the town and its Christian community ceased to exist. In practice, these titular bishops held jurisdiction over Orthodox Christian communities located elsewhere. Since 2012, the title "Bishop of Nyssa" is held by the bishop of the American Carpatho-Russian Orthodox Diocese.[8]