Sarr averaged 3.2 points and 3.0 rebounds per game as a freshman at Wake Forest. He gained 20 pounds going into his sophomore season.[8] As a sophomore, Sarr started 16 games and averaged 6.2 points and 5.5 rebounds per game, leading the team with 25 blocks.[9] On 29 February 2020, Sarr scored a career-high 37 points and grabbed 17 rebounds in a 84–73 victory over Notre Dame.[10] As a junior, Sarr averaged 13.7 points and 9.0 rebounds per game and had 11 double-doubles. He was named to the Third Team All-ACC. After coach Danny Manning was fired, Sarr entered the transfer portal. In May 2020, he announced he was transferring to Kentucky after receiving interest from Duke, Baylor, Florida State and Gonzaga. Sarr applied for a waiver for immediate eligibility at Kentucky.[11] He, along with fellow transfer Jacob Toppin, received immediate eligibility on 21 October 2020.[12] Sarr averaged 10.8 points, 5.2 rebounds and 1.2 blocks per game. He declared for the 2021 NBA draft, forgoing the additional season of eligibility granted by the NCAA due to the COVID-19 pandemic.[13]
On 27 December, Sarr signed a 10-day contract with the Thunder[18] and re-joined the Blue on 6 January 2022.[19] Three days later, he signed a second 10-day contract with the Thunder.[20] He was reacquired and activated by the Oklahoma City Blue on 19 January.[19]
On 21 February 2022, Sarr signed a two-way contract with the Thunder.[21] He was waived by the Thunder on 6 April 2022.[22]
On 7 September 2022, the Portland Trail Blazers announced that they had signed Sarr.[24] On 13 October, the Trail Blazers announced that they had converted their contract with Sarr to a two-way contract.[25] On 18 November, the Trail Blazers announced that they had waived Sarr. He never played a game for the team.[26]
On 11 January 2023, Sarr was re-acquired by the Oklahoma City Blue.[27] On 13 February, he signed a two-way contract with the Oklahoma City Thunder[28] and on 21 August, he signed another two-way contract with the Thunder.[29]
In the 2023–24 NBA season, Sarr made 15 appearances for the Thunder, averaging 2.3 points, 2.4 rebounds, and 0.1 assists in 6.5 minutes per game. On 15 April 2024, Sarr suffered a ruptured Achilles in the OKC Blue's G-League Finals victory over the Maine Celtics.[30]
Sarr is of Senegalese descent.[31] His father played professional basketball in France while his younger brother Alex plays for the NBA's Washington Wizards.[3]