Share to:

Pemafibrate

Pemafibrate
Clinical data

Trade names	Parmodia
Other names	K-13675
Routes of administration	Oral
ATC code	C10AB12 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name (2R)-2-[3-({1,3-Benzoxazol-2-yl[3-(4-methoxyphenoxy)propyl]amino}methyl)phenoxy]butanoic acid
CAS Number	848259-27-8
ChemSpider	9700824
UNII	17VGG92R23
KEGG	D10711
ChEBI	CHEBI:228365
ChEMBL	ChEMBL247951
CompTox Dashboard (EPA)	DTXSID00233891
Chemical and physical data
Formula	C₂₈H₃₀N₂O₆
Molar mass	490.556 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC[C@H](C(=O)O)Oc1cccc(c1)CN(CCCOc2ccc(cc2)OC)c3nc4ccccc4o3
InChI InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1 Key:ZHKNLJLMDFQVHJ-RUZDIDTESA-N

Pemafibrate, sold under the brand namd Parmodia, is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It is developed and marketed by Kowa Pharmaceuticals.^[1]

In July 2017, Pharmaceuticals and Medical Devices Agency approved it in Japan.^[2]^{[failed verification]}

References

^ Yamashita S, Masuda D, Matsuzawa Y (January 2020). "Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases". Current Atherosclerosis Reports. 22 (1): 5. doi:10.1007/s11883-020-0823-5. PMC 6978439. PMID 31974794.
^ Pemafibrate Archived 2018-02-05 at the Wayback Machine, pharmacodia.com

Lipid-lowering agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe Hyzetimibe SCH-48461
Bile acid sequestrants/resins (LDL)	Colesevelam Colestilan Colestipol Colestyramine Colextran Soluble fiber such as psyllium and glucomannan

Liver

Statins (HMG-CoA reductase, LDL)	Atorvastatin Cerivastatin^‡ Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin^#
Niacin and derivatives (HDL and LDL)	Acipimox Aluminium nicotinate Niacin Niceritrol Nicofuranose Nicotinyl alcohol
MTTP inhibitors (VLDL)	Dirlotapide Lomitapide Mitratapide
ATP citrate lyase inhibitors (LDL)	Bempedoic acid
Thyromimetics (VLDL)	Dextrothyroxine^‡ Resmetirom

Blood vessels

PPAR agonists (LDL)

Fibrates	Aluminium clofibrate Bezafibrate Choline fenofibrate Ciprofibrate Clinofibrate Clofibrate^‡ Clofibride Etofibrate Fenofibrate Gemfibrozil Nafenopin Pemafibrate Ronifibrate Simfibrate
Others	GW501516^§

CETP inhibitors (HDL)

PCSK9 inhibitors (LDL)

ANGPTL3 inhibitors (LDL/HDL)

Evinacumab

Combinations

Other

Alipogene tiparvovec
Azacosterol
Azalanstat
Benfluorex^‡
Darapladib^§
Lapaquistat^§
Magnesium pyridoxal 5-phosphate glutamate
Meglutol
Mipomersen
Omega−3-acid ethyl esters
Policosanol
Probucol
Tiadenol
Triparanol^‡
Volanesorsen

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

v t e PPARTooltip Peroxisome proliferator-activated receptor modulators
PPARαTooltip Peroxisome proliferator-activated receptor alpha	Agonists: 15-HETE 15-HpETE Aleglitazar Aluminium clofibrate Arachidonic acid Bezafibrate Chiglitazar Clofibrate CP-775146 Daidzein DHEA (prasterone) (in rodents) Elafibranor Etomoxir Fenofibrate Genistein Gemfibrozil GW-7647 Lanifibranor Leukotriene B₄ LG-101506 LG-100754 Lobeglitazone Muraglitazar Oleylethanolamide Palmitoylethanolamide Pemafibrate Perfluorononanoic acid Perfluorooctanoic acid Pioglitazone Saroglitazar Sodelglitazar Tesaglitazar Tetradecylthioacetic acid Troglitazone WY-14643 Antagonists: GW-6471 MK-886
PPARδTooltip Peroxisome proliferator-activated receptor delta	Agonists: 15-HETE 15-HpETE Arachidonic acid Bezafibrate Daidzein Elafibranor Fonadelpar Genistein GW-0742 GW-501516 L-165,041 Lanifibranor LG-101506 Seladelpar Sodelglitazar Tetradecylthioacetic acid Antagonists: FH-535 GSK-0660 GSK-3787
PPARγTooltip Peroxisome proliferator-activated receptor gamma	Agonists: 5-Oxo-ETE 5-Oxo-15-hydroxy-ETE 15-Deoxy-Δ^12,14-prostaglandin J₂ 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein Darglitazone Edaglitazone Efatutazone Englitazone Etalocib Farglitazar Genistein GW-1929 Ibuprofen Imiglitazar Indeglitazar Lanifibranor LG-100268 LG-100754 LG-101506 Lobeglitazone Muraglitazar (muroglitazar) nTZDpa Naveglitazar Netoglitazone Oxeglitazar Peliglitazar Pemaglitazar Perfluorononanoic acid Pioglitazone Prostaglandin J₂ Ragaglitazar Reglitazar Rivoglitazone Rosiglitazone RS5444 Saroglitazar Sipoglitazar Sodelglitazar Telmisartan Tesaglitazar Troglitazone SPPARMsTooltip Selective PPARγ modulator: BADGE EPI-001 INT-131 MK-0533 S26948 Antagonists: FH-535 GW-9662 SR-202 T-0070907 Unknown: SR-1664
Non-selective	Agonists: Ciprofibrate Clinofibrate Clofibride Englitazone Etofibrate Farglitazar Netoglitazone Ronifibrate Rivoglitazone Simfibrate
See also Receptor/signaling modulators

Read other articles:

Walk Hard: The Dewey Cox Story (soundtrack)

2007 film soundtrack album Walk Hard: The Dewey Cox Story – Original Motion Picture SoundtrackSoundtrack album to Walk Hard: The Dewey Cox Story by John C. Reilly (credited to Dewey Cox)ReleasedOctober 30, 2007Genre Comedy rock rockabilly[1] rock and roll[2] folk country psychedelic pop[2] countrypolitan[1] disco[1][2] LabelColumbiaProducer Judd Apatow (exec.) John C. Reilly (exec) Michael Andrews Jake Kasdan Professional ratingsReview...

Di Batas Angan-Angan

Di Batas Angan-AnganAlbum studio karya Keenan NasutionDirilisNovember 1978GenrePopDurasi31:33 (versi piringan hitam)LabelDuba Records (versi kaset)Gelora Seni (versi piringan hitam)Kronologi Keenan Nasution Di Batas Angan-Angan(1978) Tak Semudah Kata-Kata(1979)Tak Semudah Kata-Kata1979 Di Batas Angan-Angan adalah album perdana dari penyanyi Keenan Nasution yang dirilis pada tahun 1978 di bawah label Duba Records. Album Di Batas Angan-Angan ditempatkan pada peringkat ke-44 dalam daftar 150...

Альберт фон Буксгевден

У Вікіпедії є статті про інших людей з іменем Альберт. Альберт Герб Єпископ Ікскюлльський 1199 — 1201 Церква: Римо-Католицька Церква Попередник: Бертольд Шульте Єпископ Ризький 1201 — 17 січня 1229 Церква: Римо-Католицька Церква Наступник: Ніколаус фон Науен Дія�...

Меленківський район

Меленківський район Меленковский район Герб Мелєнковського району Прапор Меленківського району Основні дані Суб'єкт Російської Федерації: Владимирська область Утворений: 1929 Населення (2018): ▼ 33 246 Площа: 2220,92 км² Населені пункти та поселення Адміністративний центр:...

سفارة السويد في تشيلي

سفارة السويد في تشيلي السويد تشيلي الإحداثيات 33°25′14″S 70°36′23″W / 33.42067°S 70.60645°W / -33.42067; -70.60645 البلد تشيلي المكان بروفيدنسيا الموقع الالكتروني الموقع الرسمي تعديل مصدري - تعديل سفارة السويد في تشيلي هي أرفع تمثيل دبلوماسي[1] لدولة السويد لدى تشي�...

Universal Entertainment

Universal Entertainment Création 1969 Fondateurs Kazuo Okada (en) Forme juridique Kabushiki gaisha Siège social Tokyo Japon Activité Fabrication et commercialisation : Pachinkos Machines à sous Produits de jeu Jeu vidéo Produits Pachinko Société mère Okada Holdings Site web www.universal-777.com modifier - modifier le code - voir Wikidata Universal Entertainment Corporation est une entreprise japonaise qui exerce son activité dans le domaine de la fabrication et la co...

Герлос

ГерлосGerlos Герб Координати 47°13′32″ пн. ш. 12°02′03″ сх. д.H G O Країна АвстріяАвстріяЗемля ТірольОкруг ШвацПлоща 118,7 км² і 118,91 км²[1]Висота центру 1247 мНаселення 805 осіб (2021)[2]Часовий пояс UTC+1 і UTC+2Телефонний код 05284Поштовий індекс 6281Автомобіл

The SSE Hydro

OVO Hydro'The Hydro' 施設情報所在地 Exhibition WayFinnieston, GlasgowG3 8YW位置北緯55度51分37秒西経4度17分06秒 / 北緯55.860297度西経4.284926度 / 55.860297; -4.284926座標: 北緯55度51分37秒西経4度17分06秒 / 北緯55.860297度西経4.284926度 / 55.860297; -4.284926開場 2013年9月30日 (2013-09-30)所有者 SEC Ltd運用者 SEC Ltdピッチサイズ 125 m wide, 41 m high建設費 £1億2500

Joe Camel

Cigarette mascot Fictional character Joe Camel1989 magazine adFirst appearance1974 (Europe)1988 (US)Last appearance1997Created byR. J. Reynolds Tobacco Company Joe Camel (also called Old Joe) was an advertising mascot used by the R. J. Reynolds Tobacco Company (RJR) for their cigarette brand Camel. The character was created in 1974 for a French advertising campaign, and was redesigned for the American market in 1988. He appeared in magazine advertisements, clothing, and billboards among other...

Vepr

Vepr Jenis Senapan serbu Negara asal Ukraina Sejarah pemakaian Masa penggunaan 2010–sekarang Sejarah produksi Perancang National Space Agency's R&D Center for precision engineering Tahun 2003 Spesifikasi Berat 3,45 kg Panjang 702 mm Panjang laras 415 mm Kaliber 5,45 x 39 mm Mekanisme Gas-Operated, Rotating bolt Rata² tembakan 600–650 peluru/min Amunisi Magazen box isi 30 butir Vepr (bahasa Ukraina: Вепр, bahasa Inggris: wild boar, bahasa Indonesia: babi ...

Keystone Cops

Keystone Cops dalam The Stolen Purse (1913). Dari kiri ke kanan: Robert Z. Leonard, Mack Sennett, Bill Haber, Henry Lehrman, ___ McAlley, Chester Franklin, Ford Sterling, Fred Mace, dan Arthur Tavares. Keystone Cops (seringkali disebut Keystone Kops) adalah kelompok polisi inkompeten, lucu dan fiksi. Kelompok tersebut tampil daalm film-film komedi bisu slapstick yang diproduksi oleh Mack Sennett untuk Keystone Film Company antara 1912 dan 1917. Referensi Bacaan tambahan Basinger, Jeanine, (19...

Mun Bhuridatta

Ven. Mun BhuridattaNama lainLuang Pu Mun (หลวงปู่มั่น)Ajahn Mun (อาจารย์มั่น)Informasi pribadiLahir(1870-01-20)20 Januari 1870Ban Khambong, Khong Chiam, Ubon Ratchathani, ThailandMeninggal11 November 1949(1949-11-11) (umur 79)Wat Pa Sutthawat, Mueang Sakon Nakhon, Sakon Nakhon, ThailandKebangsaanThaiMazhabTheravada, Dhammayutika NikayaSilsilahTradisi Hutan ThaiNama lainLuang Pu Mun (หลวงปู่มั่น)Ajahn Mun (อาจา...

Navafría

Navafría Município Símbolos Bandeira Brasão de armas Localização NavafríaLocalização de Navafría na Espanha Coordenadas 41° 03' 17 N 3° 49' 21 O País Espanha Comunidade autónoma Castela e Leão Província Segóvia Características geográficas Área total 30,50 km² População total (2021) [1] 299 hab. Densidade 9,8 hab./km² Código postal 40161 Código do INE 40139 Website www.navafria.es Navafría é um município ...

Nigga Please

This article is about the album by Ol' Dirty Bastard. For the phrase, see Nigga, please. 1999 studio album by Ol' Dirty BastardNigga PleaseStudio album by Ol' Dirty BastardReleasedSeptember 14, 1999 (1999-09-14)StudioQuad Recording, Chung King Studios, 36 Chambers (New York City)American (Los Angeles)GenreHip hopLength47:49LabelElektraProducerBuddha MonkDat Nigga RebDLFlavahood ProductionsIrv GottiMr. FingersThe NeptunesRZATrue MasterOl' Dirty Bastard chronology Re...

Irhazer

Straßenszene im Dorf Anoumakaram in der Landschaft Irhazer (2018) Der Irhazer (auch: Erhazer, Ighader, Ighazer) ist eine Landschaft in Zentral-Niger. Inhaltsverzeichnis 1 Lage, Berge und Gewässer 2 Natur und Klima 3 Besiedlung 4 Literatur 5 Weblinks 6 Einzelnachweise Lage, Berge und Gewässer Die weitläufige Landschaft wird im Nordosten von Hochgebirge Aïr und im Südwesten von der Geländestufe Tiguidit begrenzt. Im Süden schließt die Landschaft Tegama, im Südwesten die Landschaft Tad...

Miss International

Artikel ini bukan mengenai Miss Grand International. Artikel ini bukan mengenai Miss Intercontinental. Untuk kompetisi tahun ini, lihat Miss International 2023. Miss InternationalSingkatanMITanggal pendirian12 Agustus 1960; 63 tahun lalu (1960-08-12)Didirikan di Tokyo, JepangTipeKontes kecantikanKantor pusatTokyo, JepangLokasi JepangBahasa resmi InggrisPresidenAkemi ShimomuraSlogan/MottoLove, Peace and BeautyAfiliasiMiss Paris GroupSitus webwww.miss-international.org/en/ Miss Intern...

The Bones (song)

2019 single by Maren Morris The BonesSingle by Maren Morrisfrom the album Girl ReleasedFebruary 22, 2019 (2019-02-22)GenrePopcountry[1]Length3:17LabelColumbia NashvilleSongwriter(s)Maren MorrisJimmy RobbinsLaura VeltzProducer(s)Greg KurstinMaren Morris singles chronology Girl (2019) The Bones (2019) To Hell & Back (2020) Hozier singles chronology Dinner & Diatribes(2019) The Bones(2019) Jackboot Jump(2019) Alternate coverOriginal cover artwork Music videoThe...

Vowel

Sound in spoken language, articulated with an open vocal tract This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (November 2017) (Learn how and when to remove this template message) IPA: Vowels Front Central Back Close i y ɨ ʉ ɯ u Near-close ɪ ʏ ʊ Close-mid e ø ɘ ɵ ɤ o Mid e̞ ø̞ ə ɤ̞ o̞ Open-mid ɛ œ ɜ ɞ ʌ ɔ Near-open æ ɐ Open a ɶ ä ɑ ...

Misionaris Hati Kudus

Netralitas artikel ini dipertanyakan. Diskusi terkait dapat dibaca pada the halaman pembicaraan. Jangan hapus pesan ini sampai kondisi untuk melakukannya terpenuhi. (Pelajari cara dan kapan saatnya untuk menghapus pesan templat ini) Misionaris Hati Kudus Yesus (M.S.C.) adalah salah satu tarekat atau kongregasi religius atau ordo keagamaan Katolik yang mempunyai nama resmi: Societas Missionariorum Sacratissimi Cordis Jesu, yang berarti: Tarekat Misionaris Hati Kudus Yesus (bahasa Latin: Congre...

Games of the Small States of Europe

Multi-sport event Games of the Small States of EuropeLogo of the eventGenreMultisport competitionsLocation(s)InternationalInaugurated1985 (1985)Previous event2023Next event2025Organised byEuropean Olympic CommitteesWebsitewww.eocgsse.org Member countries excluding Vatican City The Games of the Small States of Europe (GSSE) is a biennial multi-sport event, launched by the Republic of San Marino, organized by and featuring the National Olympic Committees of ten European small states since ...

Kembali kehalaman sebelumnya