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Perafensine

Perafensine
Skeletal formula of perafensine
Clinical data
ATC code
  • None
Legal status
Legal status
  • Abandoned
Identifiers
  • 1-phenyl-3-(1-piperazinyl)isoquinoline
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H19N3
Molar mass289.382 g·mol−1
3D model (JSmol)
  • c1ccc(cc1)c2c3ccccc3cc(n2)N4CCNCC4
  • InChI=1S/C19H19N3/c1-2-6-15(7-3-1)19-17-9-5-4-8-16(17)14-18(21-19)22-12-10-20-11-13-22/h1-9,14,20H,10-13H2
  • Key:BHHDTFRLKOTSKW-UHFFFAOYSA-N

Perafensine (INN) (code name HR-459) is a drug which was investigated as an antidepressant but was never marketed.[1] It has been reported to antagonize the effects of reserpine and to inhibit the reuptake of norepinephrine (norepinephrine reuptake inhibitor); whether it also affects the reuptake of serotonin or dopamine is unclear.[2]

See also

References

  1. ^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1585–. ISBN 978-0-412-46630-4.
  2. ^ Bondinell W, Kaiser C (1982). Chapter 5. Antidepressants. Annual Reports in Medicinal Chemistry. Vol. 17. pp. 41–50. doi:10.1016/S0065-7743(08)60487-X. ISBN 9780120405176.
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