De Wit debuted at the age of 17 with the comics series Jochem.[1] He started working for the Dutch comics magazine Eppo, for whom he drew the comedic western comic Stampede, which was later renamed De Cowboys[2] In 1983 De Wit started his long collaboration with Hanco Kolk. Together they made the humoristic historical comics series Gilles de Geus, the photo novelMannetje & Mannetje (Sidekicks in English; 1988), which was adapted into a TV sketch show for VPRO in 1989 [3] and the gag-a-day comic S1NGLE (2001), which was also adapted for television as a sitcom on NET 5. The men also presented an educational TV documentary series about drawing comics and cartoons for Teleac in 1992.[4] They also made a comics adaptation of the TV series Laat Maar Zitten for VARA TV Magazine. In 1988 they founded their own publishing company De Plaatjesmaker.[5]
His best known solo comics are De Familie Fortuin and Sigmund.[6]De Familie Fortuin (1985-1999) was a gag comic about a dysfunctional and asocial family and was published in Eppo, Wordt Vervolgd, Sjors en Sjimmie Stripblad, and Sjosji Striparazzi.[7] The scripts were written by Ruud Straatman until 1990, after which De Wit took over this work too [8] In 1994 he introduced Sigmund, a black comedygag-a-day about a cynical psychiatrist. This proved to be his breakthrough. He also made Het Mooiste Vak Ter Wereld (The Most Beautiful Profession of All Time) about a frustrated teacher in a high school.[9]