RAD51L3

RAD51D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KZ3
Identifiers
Aliases	RAD51D, BROVCA4, R51H3, RAD51L3, TRAD, RAD51 paralog D
External IDs	OMIM: 602954; MGI: 1261809; HomoloGene: 2156; GeneCards: RAD51D; OMA:RAD51D - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,121,522 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	82,781,440 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; right testis; ; left testis; ; stromal cell of endometrium; ; ganglionic eminence; ; prefrontal cortex; ; epithelium of colon; ; right frontal lobe; ; granulocyte;
	Top expressed in
	granulocyte; ; right kidney; ; proximal tubule; ; zygote; ; secondary oocyte; ; primary oocyte; ; Rostral migratory stream; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; mesenteric lymph nodes;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; DNA strand exchange activity; single-stranded DNA binding; protein binding; four-way junction DNA binding; gamma-tubulin binding; double-stranded DNA binding; endodeoxyribonuclease activity; ATP binding;
Cellular component	cytoplasm; centrosome; replication fork; chromosome; microtubule organizing center; telomere; Rad51B-Rad51C-Rad51D-XRCC2 complex; cytoskeleton; nucleus; nucleoplasm;
Biological process	strand invasion; response to ionizing radiation; nucleotide-excision repair; reciprocal meiotic recombination; DNA recombination; interstrand cross-link repair; chromosome organization; regulation of cell cycle; cellular response to DNA damage stimulus; mitotic recombination; telomere maintenance; DNA repair; meiotic DNA recombinase assembly; double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	5892
	19364
	ENSG00000185379
	ENSMUSG00000018841
	O75771
	O55230
NM_001142571; NM_002878; NM_133627; NM_133628; NM_133629;
	NM_133630
	NM_001277938; NM_001277939; NM_001277941; NM_001277942; NM_011235
	NP_001136043; NP_002869; NP_598332
	NP_001264867; NP_001264868; NP_001264870; NP_001264871; NP_035365
	Wikidata
View/Edit Human	View/Edit Mouse

DNA repair protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinant DNA repair. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined.^[6]