RBM15

RBM15
Identifiers
Aliases	RBM15, OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15
External IDs	OMIM: 606077; MGI: 2443205; HomoloGene: 23383; GeneCards: RBM15; OMA:RBM15 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,346,681 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,240,989 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; endothelial cell; ; Brodmann area 23; ; gingival epithelium; ; Epithelium of choroid plexus; ; middle temporal gyrus; ; parietal pleura; ; visceral pleura; ; epithelium of nasopharynx;
	Top expressed in
	ciliary body; ; gastrula; ; lacrimal gland; ; submandibular gland; ; abdominal wall; ; primitive streak; ; retinal pigment epithelium; ; fossa; ; endothelial cell of lymphatic vessel; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; mRNA binding;
Cellular component	nuclear speck; nuclear membrane; membrane; nucleus; nucleoplasm; nuclear envelope; RNA N6-methyladenosine methyltransferase complex;
Biological process	branching involved in blood vessel morphogenesis; ventricular septum morphogenesis; mRNA splicing, via spliceosome; placenta blood vessel development; viral process; negative regulation of myeloid cell differentiation; spleen development; negative regulation of transcription, DNA-templated; positive regulation of transcription of Notch receptor target; regulation of alternative mRNA splicing, via spliceosome; RNA methylation; dosage compensation by inactivation of X chromosome; thrombopoietin-mediated signaling pathway; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	64783
	229700
	ENSG00000162775
	ENSMUSG00000048109
	Q96T37
	Q0VBL3
	NM_001201545; NM_022768; NM_014092
	NM_001045807
	NP_001188474; NP_073605
	NP_001039272
	Wikidata
View/Edit Human	View/Edit Mouse

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.^[5]^[6]^[7] It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m⁶A) methylation of RNAs^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162775 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048109 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691. S2CID 36236342.
^ Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. Bibcode:2001PNAS...98.5776M. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.
^ "Entrez Gene: RBM15 RNA binding motif protein 15".
^ "UniProtKB - Q96T37 (RBM15_HUMAN)". Retrieved 29 October 2018.