RBM39

RBM39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JRS, 2MHN, 4OO6, 4OZ0, 4OZ1, 4YUD
Identifiers
Aliases	RBM39, CAPER, CAPERalpha, FSAP59, HCC1, RNPC2, RNA binding motif protein 39
External IDs	OMIM: 604739; MGI: 2157953; HomoloGene: 136465; GeneCards: RBM39; OMA:RBM39 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,742,312 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	156,180,238 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; right lobe of thyroid gland; ; left ovary; ; right ovary; ; left lobe of thyroid gland; ; sural nerve; ; body of uterus; ; ventricular zone; ; canal of the cervix;
	Top expressed in
	genital tubercle; ; tail of embryo; ; neural layer of retina; ; ventricular zone; ; Rostral migratory stream; ; spermatocyte; ; neural tube; ; granulocyte; ; medullary collecting duct; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; protein binding; RNA binding;
Cellular component	microtubule cytoskeleton; nucleus; nucleoplasm; microtubule organizing center; nuclear speck; protein-containing complex;
Biological process	mRNA processing; RNA processing; regulation of transcription, DNA-templated; transcription, DNA-templated; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	9584
	170791
	ENSG00000131051
	ENSMUSG00000027620
	Q14498; Q5QP23
	Q8VH51
NM_001242599; NM_001242600; NM_004902; NM_184234; NM_184237;
	NM_184241; NM_184244; NM_001323422; NM_001323423; NM_001323424
NM_001291114; NM_001291115; NM_133242; NM_001362763; NM_001362764;
	NM_001362765; NM_001362766; NM_001362767; NM_001362768; NM_001362769
NP_001229528; NP_001229529; NP_001310351; NP_001310352; NP_001310353;
	NP_004893; NP_909122
NP_001278043; NP_001278044; NP_573505; NP_001349692; NP_001349693;
	NP_001349694; NP_001349695; NP_001349696; NP_001349697; NP_001349698
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.^[5]^[6]

Function

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.^[6]

Interactions

RBM39 has been shown to interact with Estrogen receptor alpha,^[7] Estrogen receptor beta^[7] and C-jun.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131051 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027620 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest. 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425. PMID 8227358.
^ ^a ^b "Entrez Gene: RBM39 RNA binding motif protein 39".
^ ^a ^b ^c Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.

Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW (2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Mol. Cell. 17 (3): 429–39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343.
Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.