Having spent part of his youth career with Academia Crespo, Loaiza began his senior career with Patriotas of Categoría Primera A.[3] His professional debut came on 2 February 2013 during a 1–1 draw with Boyacá Chicó, which was the first of thirteen appearances in all competitions during the 2013 Categoría Primera A season.[1][4] He scored two goals in the subsequent campaign, notably netting his first in a win against Atlético Huila in February 2014; the other came two months later in a 2–2 versus Envigado.[1] He remained with Patriotas for the next three campaigns, taking his total appearance tally for them to one hundred and twenty-nine.[1]
2017 saw Atlético Nacional complete the signing of Loaiza.[1][5] Thirty-one appearances followed across 2017 and 2018.[1] In December 2018, Loaiza agreed a loan move to San Lorenzo of the Argentine Primera División; effective from January 2019.[6][7] He played seventeen times for them.[1] On 25 July, Loaiza penned a permanent contract with fellow Argentine top-flight team Defensa y Justicia; signing for three years.[8] Loaiza left Defense at the end of June 2022, to join fellow league club Lanús on a deal until the end of 2025.[9]
International career
Loaiza represented the Colombia U23s at international level under manager Carlos Restrepo.[3] He was part of the squad that won a 2015 international friendly tournament in China.[10] In May 2019, Loaiza received his first call-up to the senior team from Carlos Queiroz ahead of the Copa América in Brazil.[11]