The San Jerónimo Department (in Spanish, Departamento San Jerónimo) is an administrative subdivision (departamento) of the province of Santa Fe, Argentina. It is located in the center-south of the province. It limits with the Paraná River in the east; and from there (going clockwise) with the departments of San Lorenzo and Iriondo (south), Belgrano (southwest), San Martín (west), and Las Colonias and La Capital (north).