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Simple Modular Architecture Research Tool

SMART
Content
DescriptionIdentification scheme for protein domains.
Data types
captured		Protein domains
Organismsall
Contact
Research centerEuropean Molecular Biology Laboratory
Primary citationPMID 18978020
Access
Websitehttp://smart.embl-heidelberg.de
Miscellaneous
LicenseFree to academics, but not commercial users
Version7
Curation policyYes

Simple Modular Architecture Research Tool (SMART) is a biological database that is used in the identification and analysis of protein domains within protein sequences.[1][2] SMART uses profile-hidden Markov models built from multiple sequence alignments to detect protein domains in protein sequences. The most recent release of SMART contains 1,204 domain models.[3] Data from SMART was used in creating the Conserved Domain Database collection and is also distributed as part of the InterPro database.[4] The database is hosted by the European Molecular Biology Laboratory in Heidelberg.

References

  1. ^ Schultz J, Milpetz F, Bork P, Ponting CP (May 1998). "SMART, a simple modular architecture research tool: identification of signaling domains" (PDF). Proc. Natl. Acad. Sci. U.S.A. 95 (11): 5857–64. Bibcode:1998PNAS...95.5857S. doi:10.1073/pnas.95.11.5857. PMC 34487. PMID 9600884.
  2. ^ Letunic I, Doerks T, Bork P (January 2009). "SMART 6: recent updates and new developments". Nucleic Acids Res. 37 (Database issue): D229–32. doi:10.1093/nar/gkn808. PMC 2686533. PMID 18978020.
  3. ^ Letunic, Ivica; Doerks, Tobias; Bork, Peer (January 2015). "SMART: recent updates, new developments and status in 2015". Nucleic Acids Research. 43 (Database issue): D257–260. doi:10.1093/nar/gku949. ISSN 1362-4962. PMC 4384020. PMID 25300481.
  4. ^ Mulder NJ, Apweiler R, Attwood TK, et al. (September 2002). "InterPro: an integrated documentation resource for protein families, domains and functional sites". Brief. Bioinformatics. 3 (3): 225–35. doi:10.1093/bib/3.3.225. PMID 12230031.


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