^Ockrim J, Lalani EN, Abel P (2006). "Therapy Insight: parenteral estrogen treatment for prostate cancer--a new dawn for an old therapy". Nat Clin Pract Oncol. 3 (10): 552–63. doi:10.1038/ncponc0602. PMID17019433. S2CID6847203. Gynecomastia can be effectively prevented by the use of pretreatment radiotherapy given as a single or fractionated therapy. The side effects of this therapy are minimal, and consist mostly of temporary skin discoloration.56