Share to:

TRIP10

TRIP10

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CT4, 2EFK, 2KE4

Identifiers

TRIP10, CIP4, HSTP, STOT, STP, TRIP-10, thyroid hormone receptor interactor 10

External IDs

OMIM: 604504; MGI: 2146901; HomoloGene: 99728; GeneCards: TRIP10; OMA:TRIP10 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	6,737,925 bp^[1]
Band	19p13.3	End	6,751,530 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 D	Start	57,556,455 bp^[2]
Band	17\|17 D	End	57,570,665 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

gastrocnemius muscle

gastric mucosa

apex of heart

ectocervix

Descending thoracic aorta

muscle layer of sigmoid colon

right coronary artery

ascending aorta

right ovary

Top expressed in

interventricular septum

muscle of thigh

skeletal muscle tissue

triceps brachii muscle

lip

temporal muscle

ankle

sternocleidomastoid muscle

extraocular muscle

digastric muscle

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding lipid binding GTPase activator activity
Cellular component	cytoplasm cytosol Golgi apparatus cell projection intracellular membrane-bounded organelle membrane plasma membrane nucleoplasm cell cortex perinuclear region of cytoplasm lysosome phagocytic cup cytoskeleton extracellular exosome
Biological process	endocytosis cell communication regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity actin cytoskeleton organization membrane organization
Sources:Amigo / QuickGO

Species

Human

Mouse


9322


106628


ENSG00000125733


ENSMUSG00000019487


Q15642


Q8CJ53

RefSeq (mRNA)


NM_001288962 NM_001288963 NM_004240


NM_001242389 NM_001242390 NM_001242391 NM_134125

RefSeq (protein)


NP_001275891 NP_001275892 NP_004231


NP_001229318 NP_001229319 NP_001229320 NP_598886

Location (UCSC)

Chr 19: 6.74 – 6.75 Mb

Chr 17: 57.56 – 57.57 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.^[5]^[6]^[7]^[8]

Interactions

TRIP10 has been shown to interact with STAT3,^[9] Wiskott-Aldrich syndrome protein,^[10] Huntingtin,^[11] CDC42,^[6]^[10] AKAP9^[12] and RHOQ.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125733 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019487 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
^ ^a ^b Aspenstrom P (August 1997). "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton". Curr Biol. 7 (7): 479–87. doi:10.1016/S0960-9822(06)00219-3. PMID 9210375. S2CID 14268690.
^ Tsuji E, Tsuji Y (April 2001). "Molecular cloning and chromosomal localization of human salt-tolerant protein". Genetica. 108 (3): 259–62. doi:10.1023/A:1004132919896. PMID 11294612. S2CID 22725257.
^ "Entrez Gene: TRIP10 thyroid hormone receptor interactor 10".
^ Chung, Young-Hwa; Cho Nam-hyuk; Garcia Maria Ines; Lee Sun-Hwa; Feng Pinghui; Jung Jae U (June 2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12). United States: 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. ISSN 0022-538X. PMC 416526. PMID 15163742.
^ ^a ^b Tian, L; Nelson D L; Stewart D M (March 2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. 275 (11). UNITED STATES: 7854–61. doi:10.1074/jbc.275.11.7854. ISSN 0021-9258. PMID 10713100.
^ Holbert, Sébastien; Dedeoglu Alpaslan; Humbert Sandrine; Saudou Frédéric; Ferrante Robert J; Néri Christian (March 2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5). United States: 2712–7. Bibcode:2003PNAS..100.2712H. doi:10.1073/pnas.0437967100. ISSN 0027-8424. PMC 151406. PMID 12604778.
^ Larocca, M Cecilia; Shanks Ryan A; Tian Lan; Nelson David L; Stewart Donn M; Goldenring James R (June 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6). United States: 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN 1059-1524. PMC 420101. PMID 15047863.
^ Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20). United States: 12835–40. Bibcode:2002PNAS...9912835C. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tian L, Nelson DL, Stewart DM (2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. 275 (11): 7854–61. doi:10.1074/jbc.275.11.7854. PMID 10713100.
Linder S, Hüfner K, Wintergerst U, Aepfelbacher M (2001). "Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages". J. Cell Sci. 113 Pt 23 (23): 4165–76. doi:10.1242/jcs.113.23.4165. PMID 11069762.
Richnau N, Aspenström P (2001). "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1". J. Biol. Chem. 276 (37): 35060–70. doi:10.1074/jbc.M103540200. PMID 11431473.
Yuan R, Fan S, Achary M, et al. (2001). "Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage". Cancer Res. 61 (21): 8022–31. PMID 11691828.
Wang L, Rudert WA, Grishin A, et al. (2002). "Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms". Biochem. Biophys. Res. Commun. 293 (5): 1426–30. doi:10.1016/S0006-291X(02)00398-4. PMID 12054674.
Chang L, Adams RD, Saltiel AR (2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12835–40. Bibcode:2002PNAS...9912835C. doi:10.1073/pnas.202495599. PMC 130546. PMID 12242347.
Dombrosky-Ferlan P, Grishin A, Botelho RJ, et al. (2003). "Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup". Blood. 101 (7): 2804–9. doi:10.1182/blood-2002-03-0851. PMID 12456510.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Holbert S, Dedeoglu A, Humbert S, et al. (2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2712–7. Bibcode:2003PNAS..100.2712H. doi:10.1073/pnas.0437967100. PMC 151406. PMID 12604778.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins". Mol. Vis. 9: 449–59. PMID 14502124.
Larocca MC, Shanks RA, Tian L, et al. (2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. PMC 420101. PMID 15047863.
Chung YH, Cho NH, Garcia MI, et al. (2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12): 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. PMC 416526. PMID 15163742.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yin X, Warner DR, Roberts EA, et al. (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.

v t e PDB gallery
2ct4: Solution structure of the SH3 domain of the Cdc42-interacting protein 4 2efk: Crystal structure of the EFC domain of Cdc42-interacting protein 4

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

Read other articles:

W. G. M. Albert Silva

W. G. M. Albert Silva

Hon.W. G. M. Albert SilvaMember of the Ceylon Parliamentfor ButtalaIn office19 April 1956 – 1960Preceded byGladwin KotelawalaSucceeded byconstituency abolishedMember of the Ceylon Parliamentfor MonaragalaIn office1960–1965Preceded byconstituency establishedSucceeded byRaja Welegama Personal detailsBornWijeweera Goonawardene Mahavidanege Albert Silva(1918-01-15)15 January 1918NationalityCeylonesePolitical partySri Lanka Freedom PartyProfessionpolitician Wijeweera Goonawardene Maha...

Arrondissement Le Marin

Arrondissement Le Marin

Le Marin Arrondissement in Frankrijk Situering Collectivité territoriale Martinique Departement Martinique Coördinaten 14°28'17NB, 60°52'1WL Algemeen Oppervlakte 409 km² Inwoners (2018) 116.803 (286 inw./km²) Onderprefectuur Le Marin Overig Aantal gemeenten 12 Insee-code 9723 Portaal Frankrijk Le Marin is een arrondissement van het Franse overzees departement Martinique. De onderprefectuur is Le Marin. Gemeenten Het arrondissement is samengesteld uit de volgende gemeenten:&...

Імбоден (регіон)

Імбоден (регіон)

Імбоден нім. Region Imboden[1] Країна Швейцарія[2] Кантон Граубюнден Номерний знак GR Населення - повне 21 500 (31 грудня 2020) Площа - повна 203.80 км² Висота - максимальна 3243 м - мінімальна 556 м Дата заснування 1 січня 2016 Код BFS B1844 Імбоден (нім. Region Imboden) — ре

Heilpaedagogik.de

Heilpaedagogik.de

heilpaedagogik.de Beschreibung Fachzeitschrift Fachgebiet Heilpädagogik und ihre wissenschaftlichen Nachbargebiete Sprache Deutsch Verlag BHP Verlag (Deutschland) Erstausgabe 1985 Erscheinungsweise vierteljährlich Verkaufte Auflage 6500 Exemplare Herausgeber Berufs- und Fachverband Heilpädagogik Weblink bhponline.de Titel der Fachzeitschrift1995 bis 2002seit 2003 heilpaedagogik.de ist eine vierteljährlich erscheinende Fachzeitschrift für Sonder- und Heilpädagogik. Sie erscheint in einer...

Franz Erhard Walther

Franz Erhard Walther

Franz Erhard Walther, 2023 Franz Erhard Walther (* 22. Juli 1939 in Fulda) ist ein deutscher Künstler (Bildhauer, Konzept-, Installations- und Prozesskünstler). Inhaltsverzeichnis 1 Leben 2 Werk 3 Rezeption 4 Auszeichnungen (Auswahl) 5 Ausstellungen (Auswahl) 6 Publikationen (Auswahl) 7 Literatur (Auswahl) 8 Einzelnachweise 9 Weblinks Leben Neben einem Modellierkurs im elterlichen (Bäckerei-)Betrieb (1954–1956) besuchte Walther 1955 Abendkurse im Zeichnen bei Rudolf Kubesch in Fulda. 195...

Winder

Winder Ciudad Lema: Ciudad de la Oportunidad[2] Ubicación en el condado de Barrow en el estado de Georgia Coordenadas 33°59′47″N 83°43′15″O / 33.9964, -83.7208Entidad Ciudad • País Estados Unidos • Estado Georgia • Condado BarrowSuperficie • Total 29.0 km² • Tierra 28.1 km² • Agua (3.1%) 0.1 km²Altitud • Media 301 m s. n. m.Población (2000) • Total 10,201 hab....

ريفيزوندولي

ريفيزوندولي الإحداثيات 41°52′16″N 14°04′03″E / 41.871111111111°N 14.0675°E / 41.871111111111; 14.0675 [1] تقسيم إداري البلد إيطاليا[2] التقسيم الأعلى مقاطعة لَكوِيلة خصائص جغرافية المساحة 32 كيلومتر مربع (9 أكتوبر 2011)[3] ارتفاع 1320 متر عدد السكان �...

Reichstagswahlen in Deutschland

Reichstagswahlen in Deutschland

Bei der Reichstagswahl bestimmte das Volk im Norddeutschen Bund bzw. Deutschen Reich von 1867 bis 1933 die Mitglieder des höchsten deutschen Parlaments, des Reichstags, in allgemeiner, gleicher (wobei das Frauenwahlrecht erst 1918 eingeführt wurde) und geheimer Wahl. Auch in der Zeit des Nationalsozialismus (1933 bis 1945) fanden Wahlen zum Reichstag statt. Es handelte sich jedoch um Scheinwahlen, da das Ergebnis bereits von vornherein feststand; der nationalsozialistische Reichstag hatte k...

باندا عملاقة

اضغط هنا للاطلاع على كيفية قراءة التصنيف باندا عملاقة حالة الحفظ أنواع مهددة بالانقراض (خطر انقراض أدنى)[1] المرتبة التصنيفية نوع[2][3] التصنيف العلمي المملكة: الحيوانات الشعبة: الحبليات العمارة: الثدييات الرتبة: الدّبيات الجنس: الباندا العملاقة النوع: الباند...

サブマージアーク溶接

サブマージアーク溶接による溶接ビード。円筒の周を溶接するために、母材を横倒しにした後回転させている。サブマージアーク溶接（サブマージアークようせつ、英語: submerged arc welding、略称：SAW）とは、アーク溶接の一種で、粒状のフラックス（融剤）と溶接ワイヤを使用する溶接である。具体的には、溶接部に沿ってフラックスを供給(弁を開くと自重で出てく...

الخريم (السوادية)

الخريم (السوادية)

قرية الخريم - قرية - تقسيم إداري البلد اليمن المحافظة محافظة البيضاء المديرية مديرية السوادية العزلة عزلة ال منصور بني وهب السكان التعداد السكاني 2004 السكان 114 • الذكور 67 • الإناث 47 • عدد الأسر 9 • عدد المساكن 6 معلومات أخرى التوقيت توقيت اليمن ...

Convento dei Cappuccini (Modica)

Convento dei Cappuccini (Modica)

Convento dei Cappuccini di Modica (RG)Convento dei Cappuccini di ModicaStato Italia RegioneSicilia LocalitàModica ReligioneCattolica TitolareMadonna delle Grazie DiocesiNoto Modifica dati su Wikidata · Manuale Il convento dei Cappuccini, con l'annessa chiesa, è un complesso religioso situato a Modica, in provincia di Ragusa. Indice 1 Storia 2 Descrizione 3 Note 4 Bibliografia 5 Collegamenti esterni Storia I cappuccini giunsero a Modica nel 1556. Il Consiglio Generale di città, i...

Hôtel Démians

Cet article est une ébauche concernant le Gard. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Pour les articles homonymes, voir Demians (homonymie). Hôtel DémiansHôtel DémiansPrésentationType Hôtel particulierPropriétaire CommunePatrimonialité Inscrit MH (1964)LocalisationPays FranceRégion Languedoc-RoussillonDépartement GardCommune NîmesAdresse 4, rue DoréeCoordonnées 43° 50′&#...

Sinologie

Dieser Artikel oder Absatz stellt die Situation in Deutschland dar. Bitte hilf uns dabei, die Situation in anderen Staaten zu schildern. Die Sinologie, auch als Chinawissenschaften oder Chinakunde (chinesisch 漢學 / 汉学, Pinyin hànxué – „Han-Kunde“) bekannt, ist ein Fachgebiet der Sprach- und Kulturwissenschaften, das im 16. Jahrhundert entstand, und sich mit den Sprachen, Schrift, Politik, Gesellschaft, Philosophie, Literatur, Wirtschaft und Geschichte d...

2019 لوزان بيلارد ماسترز

2019 لوزان بيلارد ماسترز

الصفحه دى يتيمه, حاول تضيفلها مقالات متعلقه لينكات فى صفحات تانيه متعلقه بيها. 2019 لوزان بيلارد ماسترز البلد سويسرا المكان لوزان تاريخ نوفمبر 2019 تاريخ الانتهاء 17 نوفمبر 2019 عدد المشاركين إحداثيات 46°31′00″N 6°38′00″E / 46.516669444444°N 6.6333194444444°E / 46.516669444444; 6.6333194444444 ...

Abel Magwitch

Fictional character Abel MagwitchGreat Expectations characterAbel Magwitch by 'Kyd' (c.1900)Created byCharles DickensBased onCharles Barrow (partially)In-universe informationAliasProvis, CampbellOccupationLabourer, wagoner, haymaker, hawker, petty criminal (poaching, fraud), then a successful farmerSignificant otherMollyChildrenEstellaNationalityEnglish Abel Magwitch is a major fictional character from Charles Dickens' 1861 novel Great Expectations. Synopsis Charles Dickens set his story in t...

Франсуа-Андре Венсан

Франсуа-Андре Венсан

У Вікіпедії є статті про інших людей із прізвищем Венсан. Франсуа-Андре Венсанфр. François-André Vincent Народження 30 грудня 1746(1746-12-30)[1][2][…]Париж, Королівство ФранціяСмерть 3 серпня 1816(1816-08-03)[1][2][…] (69 років) Париж, ФранціяПоховання Пер-Лашез[4] : Країна ...

Mehmed V

35th Sultan of the Ottoman Empire from 1909 to 1918 This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Mehmed V – news · newspapers · books · scholar · JSTOR (April 2018) (Learn how and when to remove this template message) Mehmed VOttoman CaliphAmir al-Mu'mininCustodian of the Two Holy MosquesPhotograph by Car...

Shenyang Metro

Public transport system in Shenyang, China You can help expand this article with text translated from the corresponding article in Chinese. (March 2023) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Do not tra...

Carshalton

Suburb of London Human settlement in EnglandCarshalton Top to bottom, left to right: the Upper Pond in Carshalton Village; the Sun public house in the conservation area; High Street, with All Saints Church in the distance; the Leoni Bridge and the Grove.CarshaltonLocation within Greater LondonPopulation29,917 (2011 Census. 3 Wards)[1]OS grid referenceTQ275645London boroughSuttonCeremonial countyGreater LondonRegionLondonCountryEnglandSovereign stateUnited...

Kembali kehalaman sebelumnya