Bryan played at Florida from 2014 to 2017. During his career he had 65 tackles, four sacks, and one interception. After his junior season in 2017, Bryan decided to forgo his senior year and enter the 2018 NFL Draft.[4][5]
Bryan was drafted by the Jacksonville Jaguars in the first round (29th overall) of the 2018 NFL Draft.[8] On July 17, 2018, Bryan signed a four-year, $10.2 million contract with the Jaguars.[9]
The Jaguars declined to exercise the fifth-year option on Bryan's contract on May 3, 2021, making him a free agent after the 2021 season.[10]
Cleveland Browns
On March 16, 2022, Bryan signed a one-year contract with the Cleveland Browns.[11] He started 16 games in 2022, recording 26 tackles and three sacks.
Indianapolis Colts
On March 17, 2023, Bryan signed a one-year contract with the Indianapolis Colts.[12] He played in all 17 games with seven starts, recording 22 tackles, two sacks, and a forced fumble.
Bryan re-signed with the Colts on March 26, 2024.[13]