O.J. Simpson's ex-wife Nicole Brown is found murdered along with younger man Ron Goldman, outside Nicole's Brentwood townhouse. Simpson is brought to the police station as a suspect. Over the course of the film, numerous flashbacks dramatize various events in Simpson's life, from his first meeting with Nicole in 1977, to growing up in San Francisco in the 1960s, to O.J. and Nicole's romance and marriage in 1985. The pair gradually descend into domestic squabbles over Simpson's selfish and controlling behavior, with Nicole suffering depression and drug use.
Following the murders (which are never shown on-camera), Simpson panics and flees with a friend, filmed by media as the infamous 'Bronco chase' and resulting in Simpson's arrest as a suspect.[5]