St.Pierre started the year wearing #48, changing his jersey to #55 in week 5, played in all 18 regular season games and the Western Division semi-final at McMahon Stadium against the Calgary Stampeders. Tim recorded his first defensive tackle on August 8 at Ivor Wynne Stadium against the Hamilton Tiger-Cats, had a career high of 3 defensive tackles versus the Saskatchewan Roughriders on August 20 and recovered his first career fumble on October 30 at Commonwealth Stadium against the Toronto Argonauts.[9] St.Pierre finished the year with 11 defensive tackles, 17 special teams tackles, a recovered fumble and 2 special teams tackles in the western semi-final.[10]
"Tim St.Pierre played valuable snaps for us last year at linebacker and is going to be our long-snapper." announced Eskimos head coach Richie Hall saying the decision to make Tim the starting long snapper "was to get versatility in all our personnel."[11] St.Pierre changed his jersey to #53 in the off season, played in 17 regular season games and finished the year with 1 defensive tackle, 13 special teams tackles, a recovered fumble[12] and was named the Eskimos Most Outstanding Special Teams Player Nominee for 2010.[13][14]
Tim St.Pierre became an eligible CFL Free Agent on February 16, 2011, after failing to come to terms on a new agreement with Eric Tillman, general manager and vice-president of football operations for the Edmonton Eskimos.[15] The General manager and Head coach, John Hufnagel of the Calgary Stampeders announced on the same day that they had signed Tim to the club and believed, “He will provide excellent depth for our football team".[16][17][18] On June 14, 2016, St. Pierre was released by the Stampeders.