UBE1L
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene .[ 5] [ 6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes : ubiquitin-activating enzymes , or E1s, ubiquitin-conjugating enzymes , or E2s, and ubiquitin-protein ligases , or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme" . Proc Natl Acad Sci U S A . 90 (13): 6071–5. Bibcode :1993PNAS...90.6071K . doi :10.1073/pnas.90.13.6071 PMC 46869 PMID 8327486 . ^ a b "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like" .
Further reading
Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res . 52 (6): 1536–41. PMID 1311632 . Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene" . Gene Expr . 4 (3): 163–75. PMC 6134375 PMID 7734949 . McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines" . Int. J. Cancer . 85 (6): 871–6. doi :10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O PMID 10709110 . Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein" . EMBO J . 20 (3): 362–71. doi :10.1093/emboj/20.3.362 . PMC 133459 PMID 11157743 . Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia" . Proc. Natl. Acad. Sci. U.S.A . 99 (6): 3806–11. Bibcode :2002PNAS...99.3806K . doi :10.1073/pnas.052011299 PMC 122605 PMID 11891284 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . 21 (5): 566–9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 . Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia" . J. Biol. Chem . 279 (18): 18178–87. doi :10.1074/jbc.M309259200 PMID 14976209 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo" . J. Virol . 79 (22): 13974–83. doi :10.1128/JVI.79.22.13974-13983.2005 . PMC 1280211 PMID 16254333 . Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem . 138 (6): 711–9. doi :10.1093/jb/mvi172 . PMID 16428300 .
