Vitor Belfort was expected to face Alan Belcher at the event. However, Belfort was pulled from the bout to face Light Heavyweight Champion Jon Jones on September 22, 2012 at UFC 152.[3] Belcher also was forced to drop out of the card due to a spinal fracture.[4]
After having their first fight end in a no contest due to an eye poke in the first round, a rematch between Phil Davis and Wagner Prado was briefly linked to UFC on FX: Browne vs. Bigfoot and then scheduled for this event.[5]
Geronimo dos Santos was scheduled to fight Gabriel Gonzaga at this event. However, dos Santos pulled out of the bout after a blood test showed that he had antibodies for Hepatitis B.[9][10][11] With no time to find a suitable replacement, Gonzaga was pulled from the card.
Erik Koch was expected to face UFC Featherweight ChampionJosé Aldo in a title fight at this event, but on August 31, 2012, Koch was forced to pull out due to injury. Former UFC Lightweight ChampionFrankie Edgar had agreed to step in for Koch and fight Aldo for the Featherweight title.[12] However, on September 11, Aldo was also forced to pull out of the event with a foot injury after being involved in a motorcycle accident.[13]
On September 12, 2012, UFC officials announced that UFC Middleweight ChampionAnderson Silva and former The Ultimate Fighter star Stephan Bonnar would fight in the main event.[14] Silva was a massive favorite going into the bout,[15] which was a three-round fight. Although all main event fights have been five-round affairs since UFC 138, UFC 153 was the exception due to the short notice.[16]
On November 4, 2012, UFC announced Bonnar had tested positive for drostanolone, and Dave Herman for marijuana. Both fighters were suspended.[17]