Support Fleet Marine Force commitments worldwide by providing both fixed-wing and rotary-wing aerial refueling capabilities in addition to assault air transport of personnel, equipment, and supplies.
On 14 January 2003, the squadron was once again called up to support Operation Iraqi Freedom. The remainder of the reserves were activated for this operation. Seven aircraft along with pilots, aircrew, and support Marines went to Bahrain to join two other KC130 squadrons. These squadrons were VMGR-234 and VMGR-352. The three squadrons would join to create the Hercules Air Group (HAG). While being a part of the HAG, VMGR-452 supported Operation Southern Watch by doing aerial refueling for aircraft patrolling the southern no-fly zone. Once Operation Iraqi Freedom commenced, the squadron transported over 3 million pounds of cargo, distributed over 3.5 million pounds of fuel in aerial refueling, over 1 million pounds of fuel for Rapid Ground Refuelers (RGRs), transported over 3,000 pax, and flew 632 sorties consisting of 1371.0 hrs. VMGR-452 also contributed in medical evacuations, and helped transport the seven prisoners-of-war out of harm's way.
On 2 December 2022, the squadron was deactivated in support of Force Design 2030.
Rottman, Gordon L. (2002). U.S. Marine Corps World War II Order of Battle - Ground and Air Units in the Pacific War, 1939 - 1945.’’. Greenwood Press. ISBN0-313-31906-5.
