Apart from her tenures, Lederberg ran for Secretary of State of Rhode Island in 1982 but lost to Susan Farmer.[5] In 1990, Lederberg was one of the candidates running for mayor of Providence.[6] Before the Democratic primary in Rhode Island, she participated in a competition where she and the other candidates became mayor of a virtual version of Providence in SimCity.[7] During her play session, Lederberg converted a power plant from conventional fuel to nuclear, built numerous police stations and accidentally demolished a church.[8] At the 1990 primary, Lederberg lost to Andrew Annaldo after an election recount was made.[9]