Palmer's best-known role is that of Dr. Lauren Lewis, a major character in the Canadian series Lost Girl (2010–2015).[4][5][6] Her television work includes made-for-TV movies The Reagans (2003) as Patti Reagan, Out of the Ashes (2003) as Didi Goldstein, and Devil's Perch (2005) as Abby. She had a recurring role in the CTV teen drama/comedy series Instant Star as rock singer Patsy Sewer (2006–2007), and was a co-lead in the Global drama The Guard as Coast Guard rescue specialist Carly Greig (2008–2009) (for which she had to conquer her fear of water).[7] Her guest appearances include the "Girl's Best Friend" episode (2011) of The CW espionage drama Nikita as Anya Vimer, a terrorist who tries to sabotage a peace summit; the "Don of the Differently Abled" episode (2011) of the HBO Canada comedy Call Me Fitz as Laura, an unhinged amputee with plans for an escort service for disabled people; and "The Shooting" (2012), the third-season finale of the CTV fantasy drama The Listener as Staff Sgt. McCoy, an investigator for Internal Affairs. She appeared as Rebecca in the "1.1: Single Lesbian Psychos" episode (2009) of the online dating web series comedy Seeking Simone.[8] After Lost Girl, she joined the main cast of science-fiction series Dark Matter as The Android (2015–2017)[9][10] and hosted After Dark, the series' online aftershow for third-season episodes.[11]
Her film roles include Annabelle in the short drama Terminal Venus (2003), Haley in the romantic comedy The Untitled Work of Paul Shepard (2010), Cheryl in the supernatural horror Devil (2010), Officer Frances Jane in the crime thriller Cold Blooded (2012), Lou in the comedy Sex After Kids (2013),[12] and Bethany in the fantasy adventure Patch Town (2014).
Palmer received the Best Actor award for Terminal Venus by the 2004 Baja Film Festival (Mexico);[13] and the Gold Medallion Acting Award for Best Actress in a Feature Film for Cold Blooded by the 2012 Bare Bones International Film Festival.[14] She was nominated in 2011 for the ACTRA Award for Outstanding Performance – Female for The Untitled Work of Paul Shepard,[15] and in 2014 by the Canadian Comedy Awards for Multimedia / Best Female Performance in a Feature for Sex After Kids.[16]
In 2013, she won "Favorite TV Actress" and "Best Tweeter" in the annual AfterEllen Visibility Awards for popularity,[17] and "Best Sci-Fi or Fantasy Actress" by Canadagraphs in its annual Best Of TV Awards.[18] She was chosen "Girl on Top 2013" by E! Entertainment Television in its popularity contest of Favorite TV Leading Ladies.[19] She was named #1 in Hello! Canada's annual 50 Most Beautiful Stars issue celebrating homegrown talent in 2014.[20] She received the Fan Choice Award for Favourite Canadian Screen Star by the 2014 Canadian Screen Awards.[21]
Her character of Lauren and Anna Silk's character of Bo, a same-sex couple on Lost Girl, were named one of CNN's all-time "Favorite TV Couples" in 2013,[22][23] and declared "Top TV Couple of 2013" in E! Entertainment Television's annual online contest.[24]
In 2014 she confirmed her relationship with Canadian film producer Alex Lalonde while thanking her and Luca, their son (Lalonde's biologically, born due to a prior relationship) when receiving an award from the Academy of Canadian Cinema and Television for her work on the show Lost Girl.[26][27]
Main role, 72 episodes additional roles: Reynard in "Original Skin" (2.09), Flora Blooms in "La Fae Époque" (4.07), Lola in "Follow the Yellow Trick Road" (5.14)
Main role, 39 episodes. additional roles: Simulated Android in episodes 1.10, 1.12, 1.13, 2.03, 2.05, 2.10; Alternate Universe Android in episodes 2.08, 3.06; Dr. Irena Shaw in episode 3.10.