POLR2G

POLR2G

La subunidad de ARN polimerasa II dirigida por ADN RPB7 es una enzima que en humanos está codificada por el gen POLR2G .[1]​[2]​

Este gen codifica la séptima subunidad más grande de la ARN polimerasa II, la polimerasa responsable de sintetizar ARN mensajero en eucariotas. En levaduras, la asociación de esta subunidad con la polimerasa en condiciones de crecimiento subóptimas indica que puede desempeñar un papel en la regulación de la función de la polimerasa.</ref>

Interacciones

Se ha demostrado que POLR2G interactúa con TAF15,[3]​ POLR2C,[4]​ POLR2H y POLR2E .

Referencias

  1. ↑ «Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology». Mol Biol Cell 6 (7): 759-75. December 1995. PMC 301239. PMID 7579693. doi:10.1091/mbc.6.7.759. 
  2. ↑ «Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization». Biochim Biophys Acta 1353 (1): 39-49. August 1997. PMID 9256063. doi:10.1016/s0167-4781(97)00041-9. 
  3. ↑ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (March 1998). «EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489-97. ISSN 0270-7306. PMC 108863. PMID 9488465. doi:10.1128/mcb.18.3.1489. 
  4. ↑ Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). «Interactions between the human RNA polymerase II subunits». J. Biol. Chem. (UNITED STATES) 272 (27): 16815-21. ISSN 0021-9258. PMID 9201987. doi:10.1074/jbc.272.27.16815. 

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