Share to:

Kernlamina

De kernlamina of nucleaire lamina is een dicht (~ 30 tot 100 nm dik) vezelachtig netwerk dat voorkomt in de celkern van dierlijke cellen. Het is opgebouwd uit stevige intermediaire filamenten en diverse membraaneiwitten. De belangrijkste functie van de kernlamina is het handhaven van structuur, vorm en beweeglijkheid van de celkern. Ook is het betrokken bij ondersteuning van belangrijke cellulaire processen zoals DNA-replicatie en celdeling. De organisatie van chromatine en de verankering van kernporiën in het celmembraan is eveneens van de kernlamina afhankelijk. De kernlamina staat in verbinding met het binnenste kernmembraan (het kernmembraan bestaat uit twee lipide dubbellagen), en op dezelfde wijze loopt het buitenmembraan over in het endoplasmatisch reticulum.

Structuur

De kernlamina bestaat uit twee componenten: laminen en lamine-geassocieerde membraaneiwitten. De lamines zijn intermediaire filamenten (type V) die kunnen worden gecategoriseerd als ofwel A-type (lamine A, C) of B-type (lamine B1, B2) volgens homologie van hun DNA-sequenties, biochemische eigenschappen en cellulaire lokalisatie tijdens de celcyclus. De intermediaire filamenten van de kernlamina verschillen van die in het cytoplasma doordat ze een verlengd staafdomein hebben (42 aminozuren langer), een kernlokaliseringssignaal aan hun C-terminus dragen en typische tertiaire structuren vertonen.

Bij gewervelden worden laminen gecodeerd door drie genen. Door middel van alternatieve splicing ontstaan ten minste zeven verschillende polypeptiden (splice-varianten), waarvan sommige specifiek zijn voor kiemcellen en een belangrijke rol spelen bij de reorganisatie van chromatine tijdens meiose. Niet alle organismen hebben hetzelfde aantal voor lamine coderende genen; Drosophila melanogaster heeft er bijvoorbeeld slechts twee, en Caenorhabditis elegans heeft er slechts een.

De lamine-geassocieerde membraaneiwitten regelen de interacties van de kernlamina met het binnenste kernmembraan. Belangrijkste van deze membraaneiwitten zijn de zogenaamde LAP1 en LAP2-eiwitten, de emerinen en de nesprinen.

Bronnen, noten en/of referenties

↑ (en) Coutinho, Henrique Douglas M & Falcão-Silva, Vivyanne S. (2009). Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model. Immunity & Ageing 6: 4. PMID 19379495. PMC 2674425. DOI: 10.1186/1742-4933-6-4.

Read other articles:

実践女子学園中学校・高等学校

「八王子実践中学校・高等学校」あるいは「実践学園中学・高等学校」とは異なります。実践女子学園中学校、高等学校北緯35度39分26.8秒東経139度42分32.7秒 / 北緯35.657444度東経139.709083度 / 35.657444; 139.709083座標: 北緯35度39分26.8秒東経139度42分32.7秒 / 北緯35.657444度東経139.709083度 / 35.657444; 139.709083過去の名称実践女学校実践女子工芸学

Philipp Siesmayer

Philipp Nikolaus Siesmayer (* 24. Oktober 1862 in Frankfurt-Bockenheim; † 2. Mai 1935) war ein deutscher Gärtner, Handelsgärtner und Gartenarchitekt. Er war der Chef des Unternehmens Gebrüder Siesmayer, das sein Vater Heinrich Siesmayer 1842 gegründet hatte. Inhaltsverzeichnis 1 Leben 2 Familie 3 Auszeichnungen 4 Literatur 5 Weblinks 6 Einzelnachweise Leben Philipp Siesmayer war das sechste von neun Kindern des Königlich-Preussischen Gartenbaudirektors Heinrich Siesmayer (1817–1900) ...

زليخة أبو ريشة

زليخة أبو ريشة معلومات شخصية الميلاد سنة 1942 (العمر 80–81 سنة) الأردن، وعكا مواطنة الأردن الحياة العملية المدرسة الأم الجامعة الأردنيةجامعة إكستر المهنة شاعرة، وكاتِبة، وكاتبة مقالات، ونسوي، وناشط في مجال حقوق المرأة تعديل مصدري - تعديل ...

الحمراء (إب)

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (ديسمبر 2018) لأماكن أخرى بنفس الاسم، انظر الحمراء (توضيح). الحمراء تقسيم إداري البلد اليمن مديرية مديرية العدين ال�...

Pickoff

Baseball defensive play For the play in various codes of football, see interception.In baseball, a pickoff is an act by a pitcher or catcher, throwing a live ball to a fielder so that the fielder can tag out a baserunner who is either leading off or about to begin stealing the next base. San Diego Padres pitcher Craig Stammen attempts to pickoff a baserunner A pickoff attempt occurs when this throw is made in an attempt to make such an out or, more commonly, to keep the runner close by making...

موتر تون غراند بريكس 2

موتر تون غراند بريكس 2 Motor Toon Grand Prix 2 غلاف اللعبة المطور بوليفوني ديجيتال الناشر سوني كمبيوتر إنترتينمنت المصمم كازنوري ياموتشي سلسلة اللعبة موتر تون غراند بريكس النظام بلاي ستيشن تاریخ الإصدار بلاي ستيشن: 24 مايو 1996 اليابان 10 يونيو 1996 أ.ش نوفمبر 1996 بلاي ستيشن نتورك (فقط بي

History of ancient Egypt

Aspect of history Part of a series on the History of Egypt Prehistoric Egypt Predynastic Period6000–3000 BC Ancient Egypt Early Dynastic Period3150–2686 BC Old Kingdom2686–2181 BC 1st Intermediate Period2181–2055 BC Middle Kingdom2055–1650 BC 2nd Intermediate Period1650–1550 BC New Kingdom1550–1069 BC 3rd Intermediate Period1069–664 BC Late Period664–332 BC Greco-Roman Egypt Argead dynasty332–310 BC Ptolemaic dynasties310–30 BC Roman and Byzantine Egypt30 BC–641 AD Sas...

Klas Pontus Arnoldson

Klas Pontus Arnoldson Grab von Klas Pontus Arnoldson Klas Pontus Arnoldson (* 27. Oktober 1844 in Göteborg; † 20. Februar 1916 in Stockholm) war ein schwedischer Journalist, Politiker und Friedensnobelpreisträger. Inhaltsverzeichnis 1 Leben 2 Werke (Auswahl) 3 Literatur 4 Weblinks 5 Einzelnachweise Leben Als Sohn eines Hausmeisters in Göteborg geboren, entstammte Arnoldson eher einfachen Verhältnissen. Nach dem Tod des Vaters 1861 war er gezwungen, die Schule abzubrechen und eine Ausbil...

Teller (magician)

American magician (born 1948) TellerTeller at CSICon 2023BornRaymond Joseph Teller (1948-02-14) February 14, 1948 (age 75)Philadelphia, Pennsylvania, U.S.Alma materAmherst CollegeYears active1974–presentParentsJoseph Teller (father)Irene B. Derrickson (mother)Websitepennandteller.com Voice of Teller Teller (born Raymond Joseph Teller; February 14, 1948) is an American magician. He is half of the comedy magic duo Penn & Teller, along with Penn Jillette, and usually does no...

Club of Angry Patriots

Hardline nationalist political movement in Russia Club of Angry Patriots Клуб рассерженных патриотовAbbreviationKRPLeaderIgor StrelkovChairmanPavel GubarevFoundersIgor StrelkovPavel GubarevMaxim KalashnikovViktor AlksnisYevgeny MikhailovMikhail AkselFounded1 April 2023 (2023-04-01)Preceded byAll-Russian National MovementIdeologyRussian nationalism[1]MilitarismJingoismColours Black Gold WhiteSloganEverything for the front, ...

Guillermo Kuitca

Argentine artist (born 1961) Guillermo KuitcaBorn (1961-01-22) January 22, 1961 (age 62)Buenos Aires, ArgentinaKnown forPainting Guillermo Kuitca (born 1961) is an Argentine artist, who continues to work and live in Buenos Aires. Kuitca's work has been shown extensively around the globe, and is included in many important public collections, including The Tate Gallery, England; The Metropolitan Museum of Art, New York, NY; Hirshhorn Museum and Sculpture Garden, Washington, DC; the No...

Aranatha

Aranatha18th Jain Tirthankara, 7th Chakravartin, 13th KamadevaShri Arnatha bhagwan, Amritsar,Punjab.Venerated inJainismPredecessorKunthunathaSuccessorMallinathaSymbolFish [1]Height30 Bows (90 Metres)Age84,000+ColorGoldenPersonal informationBornHastinapurDiedSammed ShikharJiParentsKing Sudarshan (father)Queen Devi(Mitra) (mother) Part of a series onJainism Jains History Timeline Index Philosophy Anekantavada Cosmology Ahimsa Karma Dharma Mokṣa Kevala Jnana Dravya Tattva Brahmacarya A...

1995 Christchurch mayoral election

New Zealand mayoral election 1995 Christchurch mayoral election ← 1992 14 October 1995 1998 → Turnout106,491 Candidate Vicki Buck David Ball Party Independent Independent Popular vote 96,756 4,090 Percentage 90.85 3.84 Mayor before election Vicki Buck Elected Mayor Vicki Buck The 1995 Christchurch mayoral election was part of the New Zealand local elections held that same year. In 1995, election were held for the Mayor of Christchurch plus other local governm...

Champlain Canal

Canal in New York State, US Champlain CanalLock C-12 in Whitehall, New YorkModern route of the Champlain CanalLocationNew York StateCountryUnited StatesCoordinates43°26′31″N 73°26′48″W / 43.44194°N 73.44667°W / 43.44194; -73.44667SpecificationsLock length328 feet (100 m)Lock width45 ft (14 m)Maximum boat length300 feet (91 m)Maximum boat beam43.5 feet (13.3 m)Maximum boat draft12 feet (3.7 m)Locks11StatusOpen (seasona...

Kostas Katsouranis

Kostas Katsouranis Katsouranis bermain untuk Yunani.Informasi pribadiNama lengkap Konstantinos KatsouranisTanggal lahir 21 Juni 1979 (umur 44)Tempat lahir Patras, YunaniTinggi 6 ft 0 in (1,83 m)Posisi bermain BekInformasi klubKlub saat ini PAOK F.C.Nomor 28Karier senior*Tahun Tim Tampil (Gol)1996–2002 Panachaiki 123 (14)2002–2006 AEK Athens 110 (29)2006–2009 Benfica 80 (10)2009–2012 Panathinaikos 88 (18)2013– PAOK 5 (0)Tim nasional‡2003– Yunani 101 (9) * Pena...

نور وهداية (كتاب)

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (مارس 2016) نور وهداية معلومات الكتاب المؤلف علي الطنطاوي اللغة العربية الناشر دار المنارة تاريخ النشر 2006 الموضوع دعو�...

Jaibi

American musician JaibiBornJoan Carol Pulliam(1943-02-06)February 6, 1943DiedSeptember 4, 1984(1984-09-04) (aged 41)New York City, USOther namesJoan BatesJoan BanksJoan Pulliam MyerSpouses Anthony Bates Sr. Larry Banks (m. 1965) ChildrenThree, with Bates, Sr.Corey Banks, with Larry BanksMusical careerGenresR&B, soulOccupation(s)Singer, songwriter, computer programmerInstrument(s)VocalsYears active1964–1968LabelsKapp RecordsFormerly ofThe Pleasure...

Adalat (1976 film)

1976 film directed by Narendra Bedi AdalatDirected byNarendra BediProduced byA. K. NadiadwalaStarringAmitabh BachchanWaheeda RehmanNeetu SinghMusic byKalyanji AnandjiCountryIndiaLanguageHindiBox office₹3.2 crores(₹72 crores or US$10 million in 2019)[1] Adalat (transl. Court) is a 1976 Indian Hindi-language action drama film directed by Narendra Bedi.[2] The film stars Amitabh Bachchan in a double role as both father & Son and he received a Filmfare nomination as ...

Second Generation (film)

For other uses, see Second generation. British TV series or programme Second GenerationUS DVD posterGenreDramaWritten byNeil BiswasDirected byJon SenStarringParminder NagraChristopher SimpsonDanny DyerTheme music composerNitin SawhneyCountry of originUnited KingdomOriginal languagesEnglishBengaliNo. of episodes2ProductionProducerCatherine WearingCinematographySean BobbittEditorDave KingRunning time136 minutesProduction companyThe Oxford Film CompanyBudget£2.5 millionOriginal releaseNetw...

Infeksi

InfeksiGambar mikroskop elektron yang diwarnai menunjukkan sporozoit malaria yang berpindah melalui epitelium usus tikus.Informasi umumSpesialisasiPenyakit infeksiPenyebabAgen infeksi (patogen)PengobatanAntibiotik, antivirus, antijamur, antiprotozoa, dan antelmintik Infeksi atau jangkitan adalah serangan dan perbanyakan diri yang dilakukan oleh patogen pada tubuh makhluk hidup.[1] Patogen penyebab infeksi di antaranya mikroorganisme seperti virus, prion, bakteri, dan fungi. Sementara ...

Kembali kehalaman sebelumnya