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Colestiramina

Colestiramina
Alerta sobre risco à saúde
Identificadores
Número CAS 11041-12-6
DrugBank DB01432
Código ATC C10AC01
Propriedades
Fórmula molecular (C22H28ClN)x
Solubilidade em água Insolúvel [1]
Solubilidade insolúvel em diclorometano e etanol [1]
Farmacologia
Meia-vida biológica 1 h
Excreção fezes
Riscos associados
Frases R -
Frases S S22, S24/25
LD50 > 4000 mg·kg-1 (rato, per os) [2]
> 4000 mg·kg-1 (camundongo, Intraperitoneal) [2]
Página de dados suplementares
Estrutura e propriedades n, εr, etc.
Dados termodinâmicos Phase behaviour
Solid, liquid, gas
Dados espectrais UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão
Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

Colestiramina é um fármaco sequestrador de ácidos biliares, que se liga a bile no trato gastrointestinal para impedir a sua reabsorção. É uma resina de troca aniônica forte, o que significa que ele pode trocar ânions cloreto de sua aniônicos com ácidos biliares no trato gastrointestinal e atrai-o fortemente na matriz de resina. O grupo funcional da resina de troca é um grupo de amônio quaternário ligado a um copolímero de estireno-divinilbenzeno inerte.

Referências

  1. ↑ a b Europäische Arzneibuch-Kommission, ed. (2006). EUROPÄISCHE PHARMAKOPÖE 5. AUSGABE. 5.0 - 5.7. [S.l.: s.n.] 
  2. ↑ a b (en) « Colestiramina » em ChemIDplus
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