Share to: share facebook share twitter share wa share telegram print page

Cinarizină

Cinarizină
Identificare
Număr CAS298-57-7[1]  Modificați la Wikidata
PubChem1547484[2]  Modificați la Wikidata
DrugBankDB00568  Modificați la Wikidata
ChemSpider1264793[3]  Modificați la Wikidata
UNII3DI2E1X18L[1]  Modificați la Wikidata
KEGGD01295[4]  Modificați la Wikidata
ChEMBLCHEMBL43064[5]  Modificați la Wikidata
Cod ATCN07CA02[6]  Modificați la Wikidata
SMILES
C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4[2]  Modificați la Wikidata
InChI
InChI=InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+[2]  Modificați la Wikidata
Date chimice
FormulăC₂₆H₂₈N₂[2]  Modificați la Wikidata
Masă molară368,225 u.a.m.[2]  Modificați la Wikidata
Modifică date / text Consultați documentația formatului

Cinarizina este un antihistaminic H1 și un blocant al canalelor de calciu derivat de piperazină,[7] fiind utilizată în tratamentul răului de mișcare, amețelilor și al vertijului.[8][9] Mai este utilizată în boli vasculare periferice (cu claudicație intermitentă și extremități reci) și în tulburări vasospastice.[10]

A fost sintetizată pentru prima oară de Janssen Pharmaceutica în anul 1955.

Utilizări medicale

Cinarizina este utilizată ca tratament în:

Note

  1. ^ a b c d cinnarizine (în engleză), Global Substance Registration System, accesat în  
  2. ^ a b c d e f g h i j k l m n „Cinarizină”, cinnarizine (în engleză), PubChem, accesat în  
  3. ^ a b cinnarizine (în engleză), ChemSpider, accesat în  
  4. ^ a b cinnarizine (în engleză), ChEBI, accesat în  
  5. ^ a b CINNARIZINE (în engleză), ChEMBL, accesat în  
  6. ^ a b Cinnarizine (în engleză), DrugBank,  
  7. ^ Terland O, Flatmark T (iunie 1999). „Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles”. Neuropharmacology. 38 (6): 879–82. doi:10.1016/s0028-3908(98)00233-0. PMID 10465691. 
  8. ^ „Cinnarizine”. The American Society of Health-System Pharmacists. Accesat în februarie 2020. 
  9. ^ „Cinnarizine”. DrugBank - Canadian Institutes of Health Research. Accesat în februarie 2020. 
  10. ^ a b [httpshttps://www.anm.ro/_/_RCP/RCP_8931_11.05.16.pdf „Rezumatul caracteristicilor produsului - STUGERON 25 mg comprimate”] (PDF). Agenția Națională a Medicamentului și a Dispozitivelor Medicale din România. Accesat în februarie 2020. 
  11. ^ Nicholson AN, Stone BM, Turner C, Mills SL (iunie 2002). „Central effects of cinnarizine: restricted use in aircrew”. Aviation, Space, and Environmental Medicine. 73 (6): 570–4. PMID 12056673. 
  12. ^ Wilder-Smith CH, Schimke J, Osterwalder B, Senn HJ (). „Cinnarizine for prevention of nausea and vomiting during platin chemotherapy”. Acta Oncologica. 30 (6): 731–4. doi:10.3109/02841869109092448. PMID 1958394. 
  13. ^ Pianese CP, Hidalgo LO, González RH, Madrid CE, Ponce JE, Ramírez AM, Morán LM, Arenas JE, Rubio AT, Uribe JO, Abiuso J, Hanuch E, Alegría J, Volpi C, Flaskamp R, Sanjuán AP, Gómez JM, Hernández J, Pedraza A, Quijano D, Martínez C, Castañeda JR, Guerra OJ, F GV (mai 2002). „New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study”. Otology & Neurotology. 23 (3): 357–63. doi:10.1097/00129492-200205000-00023. PMID 11981396. 
  14. ^ Arab SF, Düwel P, Jüngling E, Westhofen M, Lückhoff A (iunie 2004). „Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine”. Naunyn-Schmiedeberg's Archives of Pharmacology. 369 (6): 570–5. doi:10.1007/s00210-004-0936-3. PMID 15138660. 

Vezi și

 Acest articol legat de un medicament este un ciot. Puteți ajuta Wikipedia prin completarea lui.


v • d • m
Antihistaminice (ATC R06)
Benzimidazoli
și ftalazine
Diarilmetani

Diarilmetoxialchilamine: Bromazină  • Carbinoxamină  • Clorfenoxamină  • Clemastină  • Difenhidramină  • Difenilpiralină  • Doxilamină  • Ebastină  • Orfenadrină

Difenilmetanolpiperidine: Fexofenadină  • Terfenadină

Difenilmetilpiperazine: Buclizină  • Cetirizină (Levocetirizină)  • Clorciclizină  • Ciclizină#  • Cinarizină  • Etodroxizină  • Hidroxizină  • Meclozină  • Oxatomidă

Fenilpiridinilpropanamine: Bromfeniramină  • Clorfeniramină  • Dexbromfeniramină (+pseudoefedrină)  • Dexclorfeniramină (+betametazonă)  • Feniramină

Altele: Acrivastină  • Bamipină  • Dimetinden  • Feniltoloxamină  • Pirobutamină  • Quifenadină  • Triprolidină
Etilendiamine
Triciclice
De uz topic
v • d • m
Antiemetice (ATC A04)
Antagoniști 5-HT3
Antagoniști 5-HT
Agoniști CBD1
Antagoniști D2/D3
Antagoniști H1
Antagoniști M
Antagoniști NK1
Altele

Read other articles:

T-72

T-72 T-72 di Museum Tank Worthington, Kanada Jenis Tank Tempur Utama Negara asal Uni Soviet Sejarah pemakaian Masa penggunaan 1973–sekarang Digunakan oleh * Uni Soviet  Russia  Ukraina  Belarus  Irak  India  Korea Utara  Bulgaria  Iran  Suriah  Serbia  Bosnia Herzegovina  Kazakhstan Sejarah produksi Perancang Kartsev-Venediktov Tahun 1969–73 Produsen Uralvagonzavod Diproduksi 1971–Sekarang Jumlah produk...

 

Park Ji-soo (pemeran)

Dalam artikel ini, nama keluarganya adalah Park. Park Ji-sooLahir22 Juli 1988 (umur 35)Seoul, Korea SelatanNama lainJoyce ParkPendidikanKorea National University of Arts - TeaterPekerjaanAktrisTahun aktif2012–sekarangAgenC&CO ENS[1](2018-present)Nama KoreaHangul박지수 Hanja朴芝秀 Alih AksaraBak Ji-suMcCune–ReischauerPak Chi-su Park Ji-soo (lahir 22 Juli 1988) adalah seorang aktris Korea Selatan. Park memulai debut akting di Mai Ratima, fitur debut sutradar...

 

Hiltenfingen

Hiltenfingen Lambang kebesaranLetak Hiltenfingen di Augsburg NegaraJermanNegara bagianBayernWilayahSchwabenKreisAugsburgPemerintahan • MayorKornelius Griebl (FWV/CWU)Luas • Total14,55 km2 (562 sq mi)Ketinggian556 m (1,824 ft)Populasi (2013-12-31)[1] • Total1.456 • Kepadatan1,0/km2 (2,6/sq mi)Zona waktuWET/WMPET (UTC+1/+2)Kode pos86856Kode area telepon08232Pelat kendaraanASitus webwww.hiltenfingen.de Hil...

United News of India

United News of IndiaIndustriMedia beritaDidirikan19 Desember 1959; 63 tahun lalu (1959-12-19)PendiriDr. Bidhan Chandra RoyKantorpusat9, Rafi Marg, New Delhi-110001, IndiaSitus webwww.uniindia.com www.univarta.com www.uniurdu.com www.unikannada.com United News of India (UNI) adalah agensi berita multibahasa di India. Perusahaan tersebut didirikan pada Desember 1959 sebagai sebuah agensi berita berbahasa Inggris. Operasi komersialnya dimulai dari 21 Maret 1961. Referensi Daftar pustaka Shr...

 

الخطاب بن مرداس

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (ديسمبر 2018) هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها...

 

Marquess of Cambridge

Marquessate of Cambridge Blazon Arms: Quarterly: 1st and 4th grand-quarters, quarterly, I & IV, Gules, three Lions passant guardant, armed and langued Azure (England); II, Or, a Lion rampant Gules, armed and langued Azure, within a Double-Tressure flory counter-flory Gules (Scotland); III, Azure, a Harp Or, stringed Argent (Ireland); over all an Inescutcheon tiercé reversed i, Gules, two Lions passant guardant Or, armed and langued Azure; ii, Or, semée of Hearts Gules, a Lion rampant Az...

Friends with Benefits (film)

Frien ds with BenefitsPoster PromosiSutradara Will Gluck ProduserMartin ShaferLiz GlotzerJerry ZuckerJanet ZuckerWill GluckDitulis olehKeith MerrymanDavid A. NewmanWill GluckSkenarioKeith MerrymanDavid A. NewmanWill GluckCeritaHarley PeytonKeith MerrymanDavid A. NewmanPemeranJustin TimberlakeMila KunisPatricia ClarksonJenna ElfmanBryan GreenbergNolan GouldRichard JenkinsWoody HarrelsonPenata musikHalli CautherySinematograferMichael GradyPenyuntingTia NolanPerusahaanproduksiCastle Rock E...

 

Daftar kabupaten dan kota di Kalimantan Utara berdasarkan waktu pembentukan

Lambang Provinsi Kalimantan Utara Peta lokasi Provinsi Kalimantan Utara di Indonesia Peta lokasi Kabupaten dan kota di Kalimantan Utara Artikel utama: Daftar kabupaten di Indonesia menurut waktu pembentukan Berikut adalah artikel mengenai Daftar kabupaten dan/atau kota di Kalimantan Utara berdasarkan waktu pembentukan yang diurutkan berdasarkan abjad. Referensi berdasarkan Undang-Undang Republik Indonesia yang pertama dikeluarkan saat pembentukan kabupaten/kota tersebut meskipun terdapat peru...

 

Alashkert Football Club

Alashkert FC Datos generalesNombre Alashkert Football ClubApodo(s) AmarillosFundación 1990Refundación 2011Propietario(s) Bagratour LLCPresidente Bagrat NavoyanEntrenador Aram VoskanyanInstalacionesEstadio Estadio NairiCapacidad 6 800Ubicación Ereván, ArmeniaUniforme Titular Alternativo Tercero Última temporadaLiga Liga Premier de Armenia(2022-23) 4.ºCopa Copa de Armenia(2022-23) 1/4 Página web oficial[editar datos en Wikidata] Alashkert Stadium El Alashkert FC (en armenio: Ա...

Prime Minister of Belgium

Head of the federal government of Belgium For a list, see List of prime ministers of Belgium. Prime Minister of BelgiumEerste Minister van België (Dutch)Premier Ministre de Belgique (French)Premierminister von Belgien (German)Coat of armsState EnsignIncumbentAlexander De Croosince 1 October 2020Executive branch of the Belgian Federal GovernmentStyleMr Prime Minister (informal)His Excellency[1] (diplomatic)Member ofBelgian Federal CabinetEuropean CouncilResidenceLe...

 

Romania and the United Nations

History and relations of Romania with the United Nations Romania United Nations membershipRepresented by Romanian People's Republic(1955–1965) Socialist Republic of Romania(1965–1989) Romania(1989–present) MembershipFull memberSince14 December 1955 (1955-12-14)UNSC seatNon-permanentPermanent RepresentativeIon Jinga Romania (then the Romanian People's Republic) joined the United Nations (UN) on 14 December 1955[1] following the adoption of the United Nations Securi...

 

Department of Justice and Constitutional Development

Department of Justice and Constitutional Development List 10 other official names: Departement van Justisie en Staatkundige Ontwikkeling (Afrikaans) umNyango wezoBulungiswa nokuThuthukiswa komThethosisekelo (Southern Ndebele) iSebe lezoBulungisa noMgaqosiseko (Xhosa) uMnyango Wezobulungiswa Nokuthuthukiswa Komthethosisekelo (Zulu) Litiko Letebulungiswa Netekutfutfukiswa Kwemtsetfosisekelo (Swazi) Kgoro ya Toka le Tlhabollo ya Molaotheo (Northern Sotho) Lefapha la...

Master's FA

Canadian semi-professional soccer club Football clubMaster's FutbolFull nameMaster's Futbol AcademyNickname(s)SaintsFounded2009; 14 years ago (2009)StadiumL'Amoreaux ParkScarborough, Toronto, OntarioOwnerJunior GrovesHead CoachGiuseppe Mattace-RasoLeagueLeague1 Ontario2021League1 Ontario, 19thPlayoffs: DNQWebsiteClub website Current season Master's Futbol Academy, commonly known as Master's FA, is a Canadian semi-professional soccer club based in Scarborough, Toronto, Ontari...

 

The Rough Guide to the Music of Kenya and Tanzania

1996 compilation album by Various artistsThe Rough Guide to the Music of Kenya and TanzaniaCompilation album by Various artistsReleased5 November 1996GenreWorldLength72:04LabelWorld Music NetworkFull series chronology The Rough Guide to Irish Music(1996) The Rough Guide to the Music of Kenya and Tanzania(1996) The Rough Guide to the Music of India and Pakistan(1996) Complete list The Rough Guide to the Music of Kenya and Tanzania is a world music compilation album originally released ...

 

No Limits (Martha Munizzi album)

2006 live album by Martha MunizziNo Limits: Live [2 CD]Live album by Martha MunizziReleasedMarch 4, 2006GenreCCMLength105:52LabelSony , Martha Munizzi Music/Say The Name PublishingMartha Munizzi chronology When He Came(2004) No Limits: Live [2 CD](2006) Change the World(2008) Professional ratingsReview scoresSourceRatingAllMusic[1] No Limits: Live is a live album from Gospel music singer Martha Munizzi. The album was released on March 4, 2006. Track listing Disc 1 All songs wr...

المجلل (ملحان)

قرية المجلل  - قرية -  تقسيم إداري البلد  اليمن المحافظة محافظة المحويت المديرية مديرية ملحان العزلة عزلة بني مكار السكان التعداد السكاني 2004 السكان 311   • الذكور 163   • الإناث 148   • عدد الأسر 49   • عدد المساكن 43 معلومات أخرى التوقيت توقيت اليمن (+3 غرينيت...

 

Manor Farm, Ruislip

Historic site in Greater London, England Manor FarmThe Great Barn, built around 1280[1]Location within Greater LondonGeneral informationClassificationGrade II and II* listed buildingsLocationRuislipTown or cityGreater LondonCountryEnglandCoordinates51°34′42″N 0°25′42″W / 51.578206°N 0.428451°W / 51.578206; -0.428451Completed13th century Manor Farm is a 22-acre (8.9 ha) historic site in Ruislip, Greater London.[2] It incorporates a medie...

 

Ariane (film)

1931 film ArianeDirected byPaul CzinnerWritten byPaul CzinnerCarl MayerBased onAriane by Claude AnetProduced bySeymour NebenzahlErnst WolffStarringElisabeth BergnerRudolf ForsterAnnemarie SteinsieckCinematographyAdolf SchlasyEdited byHerbert SelpinMusic byAndré RoubaudProductioncompanyNero FilmDistributed byVereinigte Star-FilmRelease date 20 February 1931 (1931-02-20) Running time85 minutesCountryGermanyLanguageGerman Ariane is a 1931 German drama film directed by Paul Czinne...

Ricardo Legorreta

Mexican architectIn this Spanish name, the first or paternal surname is Legorreta and the second or maternal family name is Vilchis. Ricardo LegorretaBornRicardo Legorreta Vilchis(1931-05-07)May 7, 1931Mexico CityDiedDecember 30, 2011(2011-12-30) (aged 80)NationalityMexicanAlma materUniversidad Nacional Autónoma de MéxicoOccupationArchitectDesignLandscaping and brightly colored Cubist designs Ricardo Legorreta Vilchis (May 7, 1931 – December 30, 2011)[1] was a Me...

 

Joe Napolitano

Joe NapolitanoNapolitano menyutradarai sebuah episode dari Quantum Leap pada 1991LahirJoseph Ralph Napolitano(1948-11-22)22 November 1948 [1]Brooklyn, New York, AS[1]Meninggal23 Juli 2016(2016-07-23) (umur 67)Los Angeles, California, ASNama lainJ. R. NapolitanoWarga negaraAmerikaPekerjaanSutradara televisiTahun aktif1974–2016 Joseph Ralph Joe Napolitano (22 November 1948 – 23 Juli 2016) adalah seorang sutradara televisi asal Amerika Serikat yan...

 
Kembali kehalaman sebelumnya