2,7,4'-Trihidroksiizoflavanon 4'-O-metiltransferaza

2,7,4'-Trihidroksiizoflavanon 4'-O-metiltransferaza
Identifikatori
EC broj	2.1.1.212
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

2,7,4'-Trihidroksiizoflavanon 4'-O-metiltransferaza (EC 2.1.1.212, SAM:2,7,4'-trihidroksiizoflavanonska 4'-O-metiltransferaza, HI4'OMT, HMM1, MtIOMT5) je enzim sa sistematskim imenom S-adenozil-L-metionin:2,7,4'-trihidroksiizoflavanon 4'-O-metiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + 2,7,4'-trihidroksiizoflavanon

\rightleftharpoons

S-adenozil-L-homocistein + 2,7-dihidroksi-4'-metoksiizoflavanon

Ovaj enzim specifično metiluje 2,7,4'-trihidroksiizoflavanon u 4'-poziciji. On ne deluje na izoflavone. Enzim učestvuje u biosintezi formononetina .

Reference

↑ Akashi, T., Sawada, Y., Shimada, N., Sakurai, N., Aoki, T. and Ayabe, S. (2003). „cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway”. Plant Cell Physiol. 44: 103-112. PMID 12610212.
↑ Deavours, B.E., Liu, C.J., Naoumkina, M.A., Tang, Y., Farag, M.A., Sumner, L.W., Noel, J.P. and Dixon, R.A. (2006). „Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula”. Plant Mol. Biol. 62: 715-733. PMID 17001495.
↑ Liu, C.J., Deavours, B.E., Richard, S.B., Ferrer, J.L., Blount, J.W., Huhman, D., Dixon, R.A. and Noel, J.P. (2006). „Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses”. Plant Cell 18: 3656-3669. PMID 17172354.
↑ Akashi, T., VanEtten, H.D., Sawada, Y., Wasmann, C.C., Uchiyama, H. and Ayabe, S. (2006). „Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis”. Phytochemistry 67: 2525-2530.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH 2,7,4'-trihydroxyisoflavanone+4'-O-methyltransferase

[1] Akashi, T., Sawada, Y., Shimada, N., Sakurai, N., Aoki, T. and Ayabe, S. (2003). „cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway”. Plant Cell Physiol. 44: 103-112. PMID 12610212.

[2] Deavours, B.E., Liu, C.J., Naoumkina, M.A., Tang, Y., Farag, M.A., Sumner, L.W., Noel, J.P. and Dixon, R.A. (2006). „Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula”. Plant Mol. Biol. 62: 715-733. PMID 17001495.

[3] Liu, C.J., Deavours, B.E., Richard, S.B., Ferrer, J.L., Blount, J.W., Huhman, D., Dixon, R.A. and Noel, J.P. (2006). „Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses”. Plant Cell 18: 3656-3669. PMID 17172354.

[4] Akashi, T., VanEtten, H.D., Sawada, Y., Wasmann, C.C., Uchiyama, H. and Ayabe, S. (2006). „Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis”. Phytochemistry 67: 2525-2530.

[1]

[2]

[3]

[4]