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CXCL3

Hemokine (C-X-C motif) ligand 3
Identifikatori
Simbol CXCL3
Alt. simboli SCYB3, GRO3, GROg, MIP-2b, CINC-2b
Entrez 2921
HUGO 4604
OMIM 139111
RefSeq NM_002090
UniProt P19876
Drugi podaci
Lokus Hromozom 4 q21

CXCL3, hemokin (C-X-C motiv) ligand 3, je mali citokin iz CXC hemokin familije koji je poznat kao GRO3 onkogen (GRO3), GRO protein gama (GROg) i makrofagni inflamatorni protein-2-beta (MIP2b). CXCL3 kontroliše migraciju i adheziju monocit. Ovaj hemokin ostvaruje efekte na svojim ciljnim ćelijama putem interakcije sa hemokin receptorom na ćelijskoj površini koji se zove CXCR2.[1][2] CXCL3 gen je lociran na hromozomu 4 u klusteru sa drugim CXC hemokinima.[3][4]

Reference

  1. ↑ Smith DF, Galkina E, Ley K, Huo Y. GRO family chemokines are specialized for monocyte arrest from flow. Am J Physiol Heart Circ Physiol. 2005, 289(5):H1976-84. PMID: 15937099
  2. ↑ Ahuja SK, Murphy PM. The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. J Biol Chem. 1996, 23;271(34):20545-50. PMID: 8702798
  3. ↑ O'Donovan, N., Galvin, M. Morgan, J.G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. PMID: 10343098
  4. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
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