O-fosfoserin sulfhidrilaza

O-fosfoserin sulfhidrilaza
Identifikatori
EC broj	2.5.1.65
CAS broj	1071505-11-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

O-fosfoserin sulfhidrilaza (EC 2.5.1.65, O-fosfoserin(tiol)-lijaza) je enzim sa sistematskim imenom O-fosfo-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

O-fosfo-L-serin + vodonik sulfid

\rightleftharpoons

L-cistein + fosfat

Ovaj enzim je piridoksal-fosfatni protein. Enzim iz Aeropyrum pernix deluje O-fosfo-L-serin i O³-acetil-L-serin, za razliku od enzima EC 2.5.1.47, cistein sintaze, koji deluje samo na O³-acetil-L-serin.

Reference

↑ Mino, K. and Ishikawa, K. (2003). „A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. FEBS Lett. 551: 133-138. PMID 12965218.
↑ Mino, K. and Ishikawa, K. (2003). „Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. J. Bacteriol. 185: 2277-2284. PMID 12644499.
↑ Mino, K. and Ishikawa, K. (2003). „Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. Acta Crystallogr. D Biol. Crystallogr. 59: 338-340. PMID 12554945.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH O-phosphoserine+sulfhydrylase

[1] Mino, K. and Ishikawa, K. (2003). „A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. FEBS Lett. 551: 133-138. PMID 12965218.

[2] Mino, K. and Ishikawa, K. (2003). „Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. J. Bacteriol. 185: 2277-2284. PMID 12644499.

[3] Mino, K. and Ishikawa, K. (2003). „Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. Acta Crystallogr. D Biol. Crystallogr. 59: 338-340. PMID 12554945.

[1]

[2]

[3]