1-pirolidin dehidrogenaza

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PMC	članci
PubMed	članci
NCBI	proteini

1-pirolidin dehidrogenaza
1-pirolidin dehidrogenaza
Identifikatori
EC broj	1.5.1.35
CAS broj	9054-82-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

1-pirolidin dehidrogenaza (EC 1.5.1.35, gama-aminobutiraldehidna dehidrogenaza, ABALDH, YdcW) je enzim sa sistematskim imenom 1-pirolidin:NAD⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-pirolidin + NAD⁺ + 2H₂O

\rightleftharpoons

4-aminobutanoat + NADH + 2 H⁺

1-pirolidin se spontano formira iz 4-aminobutanala, posredstvom enzima EC 2.6.1.82, putrescin aminotransferaze. Ovaj enzim formira deo puta argininskog katabolizma.

Reference

^ Prieto-Santos, M.I., Martin-Checa, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1986). „A pathway for putrescine catabolism in Escherichia coli”. Biochim. Biophys. Acta. 880: 242—244. PMID 3510672.
^ Prieto, M.I., Martin, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1987). „Properties of γ-aminobutyraldehyde dehydrogenase from Escherichia coli”. Biochimie. 69: 1161—1168. PMID 3129020.
^ Samsonova, N.N., Smirnov, S.V., Novikova, A.E. and Ptitsyn, L.R. (2005). „Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase”. FEBS Lett. 579: 4107—4112. PMID 16023116.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

1-pyrroline+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Prieto-Santos, M.I., Martin-Checa, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1986). „A pathway for putrescine catabolism in Escherichia coli”. Biochim. Biophys. Acta. 880: 242—244. PMID 3510672.

[2] Prieto, M.I., Martin, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1987). „Properties of γ-aminobutyraldehyde dehydrogenase from Escherichia coli”. Biochimie. 69: 1161—1168. PMID 3129020.

[3] Samsonova, N.N., Smirnov, S.V., Novikova, A.E. and Ptitsyn, L.R. (2005). „Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase”. FEBS Lett. 579: 4107—4112. PMID 16023116.

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