2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza

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PMC	članci
PubMed	članci
NCBI	proteini

2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza
2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza
Identifikatori
EC broj	3.7.1.14
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza (EC 3.7.1.14, mhpC (gen)) je enzim sa sistematskim imenom (2Z,4E)-2-hidroksi-6-oksona-2,4-dienedioat sukcinilhidrolaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) (2Z,4E)-2-hidroksi-6-oksonona-2,4-dien-1,9-dioat + H₂O

\rightleftharpoons

(2Z)-2-hidroksipenta-2,4-dienoat + sukcinat

(2) (2Z,4E,7E)-2-hidroksi-6-oksonona-2,4,7-trien-1,9-dioat + H₂O

\rightleftharpoons

(2Z)-2-hidroksipenta-2,4-dienoat + fumarat

Ovaj enzim katalizuje jedan od koraka u degradaciji fenilpropanoidnih jedinjenja.

Reference

^ Burlingame, R. & Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113—121. PMID 6345502.
^ Burlingame, R.P., Wyman, L. and Chapman, P.J. (1986). „Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation”. J. Bacteriol. 168: 55—64. PMID 3531186.
^ Lam, W. W. Y & Bugg, T. D. H. (1994). „Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage”. J. Chem. Soc., Chem. Commun. 10: 1163—1164.
^ Lam, W.W. & Bugg, T.D. (1997). „Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase”. Biochemistry. 36: 12242—12251. PMID 9315862.
^ Ferrández, A., García, J.L. and Díaz, E. (1997). „Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12”. J. Bacteriol. 179: 2573—2581. PMID 9098055.
^ Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915—2923. PMID 9603882.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

2-hydroxy-6-oxonona-2,4-dienedioate+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Burlingame, R. & Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113—121. PMID 6345502.

[2] Burlingame, R.P., Wyman, L. and Chapman, P.J. (1986). „Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation”. J. Bacteriol. 168: 55—64. PMID 3531186.

[3] Lam, W. W. Y & Bugg, T. D. H. (1994). „Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage”. J. Chem. Soc., Chem. Commun. 10: 1163—1164.

[4] Lam, W.W. & Bugg, T.D. (1997). „Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase”. Biochemistry. 36: 12242—12251. PMID 9315862.

[5] Ferrández, A., García, J.L. and Díaz, E. (1997). „Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12”. J. Bacteriol. 179: 2573—2581. PMID 9098055.

[6] Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915—2923. PMID 9603882.

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