Aromatična-L-aminokiselinska dekarboksilaza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Aromatična-L-aminokiselinska dekarboksilaza
Aromatična-L-aminokiselinska dekarboksilaza
Identifikatori
EC broj	4.1.1.28
CAS broj	9042-64-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Aromatična-L-aminokiselinska dekarboksilaza (EC 4.1.1.28, DOPA dekarboksilaza, triptofanska dekarboksilaza, hidroksitriptofanska dekarboksilaza, L-DOPA dekarboksilaza, aromatična amino kiselinska dekarboksilaza, 5-hidroksitriptofanska dekarboksilaza, aromatična-L-amino-kiselinska karboksi-lijaza (formira triptamin)) je enzim sa sistematskim imenom aromatična-L-aminokiselina karboksi-lijaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) L-dopa

\rightleftharpoons

dopamin + CO₂

(2) 5-hidroksi-L-triptofan

\rightleftharpoons

5-hidroksitriptamin + CO₂

Ovaj enzim je piridoksal-fosfatni protein.

Reference

^ Christenson, J.G., Dairman, W. and Udenfriend, S. (1972). „On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)”. Proc. Natl. Acad. Sci. USA. 69: 343—347. PMID 4536745.
^ Lovenberg, W., Weissbach, H. and Udenfriend, S. (1962). „Aromatic L-amino acid decarboxylase”. J. Biol. Chem. 237: 89—93. PMID 14466899.
^ McGilvery, R.W. & Cohen, P.P. (1948). „The decarboxylation of L-phenylalanine by Streptococcus faecalis R”. J. Biol. Chem. 174: 813—816.
^ Sekeris, C.E. (1963). „Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifität der DOPA-Decarboxylase”. Hoppe-Seyler's Z. Physiol. Chem. 332: 70—78.
^ Weissbach, H., Bogdanski, D.F., Redfield, B.G. and Udenfriend, S. (1957). „Studies on the effect of vitamin B₆ on 5-hydroxytryptamine (serotonin) formation”. J. Biol. Chem. 227: 617—624. PMID 13462983.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Aromatic-L-amino-acid+decarboxylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Christenson, J.G., Dairman, W. and Udenfriend, S. (1972). „On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)”. Proc. Natl. Acad. Sci. USA. 69: 343—347. PMID 4536745.

[2] Lovenberg, W., Weissbach, H. and Udenfriend, S. (1962). „Aromatic L-amino acid decarboxylase”. J. Biol. Chem. 237: 89—93. PMID 14466899.

[3] McGilvery, R.W. & Cohen, P.P. (1948). „The decarboxylation of L-phenylalanine by Streptococcus faecalis R”. J. Biol. Chem. 174: 813—816.

[4] Sekeris, C.E. (1963). „Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifität der DOPA-Decarboxylase”. Hoppe-Seyler's Z. Physiol. Chem. 332: 70—78.

[5] Weissbach, H., Bogdanski, D.F., Redfield, B.G. and Udenfriend, S. (1957). „Studies on the effect of vitamin B₆ on 5-hydroxytryptamine (serotonin) formation”. J. Biol. Chem. 227: 617—624. PMID 13462983.

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